Fig. 1

A generated null distribution of AUC values from a permutation test where the class labels (e.g., patients with bipolar disorder and healthy controls) are randomly shuffled 200 times and an AUC value for each permutation is plotted. The light grey region represents the critical area with the 5% largest values. The vertical lines represent the observed AUC values from the true class labels. A Generated null-distribution for the Random Forest classification of patients with bipolar disorder against healthy control individuals. B Generated null-distribution for the Random Forest classification of patients with bipolar disorder against unaffected relatives