Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population

Tachi, Ryobu; Ohi, Kazutaka; Nishizawa, Daisuke; Soda, Midori; Fujikane, Daisuke; Hasegawa, Junko; Kuramitsu, Ayumi; Takai, Kentaro; Muto, Yukimasa; Sugiyama, Shunsuke; Kitaichi, Kiyoyuki; Hashimoto, Ryota; Ikeda, Kazutaka; Shioiri, Toshiki

doi:10.1186/s40345-023-00307-6

International Journal of Bipolar Disorders

Table 2 Differences in mitochondrial allelic frequencies among patients with BD, patients with SZ, and HCs

From: Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population

			MAF (A1)				PSYs			BD			SZ
Rs number	BP	A1/A2	PSYs	BD	SZ	HCs	OR	P_uncorr (χ²)	P _GC	OR	P_uncorr (χ²)	P _GC	OR	P_uncorr (χ²)	P _GC
rs28625645	489	A/G	0.32	0.33	0.31	0.37	0.79	0.26 (1.3)	0.42	0.85	0.62 (0.2)	0.69	0.78	0.25 (1.3)	0.47
rs3901846	499	A/G	0.022	0.039	0.017	0.051	0.43	0.12 (2.4)	0.26	0.76	0.73 (0.1)	0.78	0.33	0.083 (3.0)	0.27
rs3888511	961	G/A	0.050	0.020	0.058	0.051	0.97	0.95 (< 0.1)	0.97	0.38	0.35 (0.9)	0.44	1.15	0.75 (0.1)	0.84
rs111033179	1005	G/A	-	0.039	-	0.005	-	-	-	8.00	0.047 (4.0)	0.10	-	-	-
rs2000974	1048	A/G	0.018	-	0.023	0.005	3.56	0.23 (1.5)	0.39	-	-	-	4.64	0.13 (2.3)	0.34
rs111033358	1382	C/A	0.081	0.059	0.087	0.10	0.78	0.46 (0.6)	0.59	0.55	0.35 (0.9)	0.44	0.85	0.64 (0.2)	0.77
rs28358573	1442	A/G	0.022	0.020	0.023	0.025	0.88	0.84 (< 0.1)	0.89	0.77	0.81 (0.1)	0.84	0.91	0.90 (< 0.1)	0.93
rs200251800	1709	A/G	0.009	0	0.012	0.025	0.35	0.19 (1.7)	0.35	0	0.25 (1.3)	0.35	0.45	0.33 (0.9)	0.54
rs28358580	2416	G/A	-	0.020	-	0.010	-	-	-	1.95	0.58 (0.3)	0.65	-	-	-
rs200221487	2772	A/G	0.090	0.020	0.11	0.066	1.39	0.37 (0.8)	0.52	0.28	0.20 (1.6)	0.29	1.76	0.13 (2.3)	0.33
rs199713564	2831	A/G	0.014	0.020	0.012	0.051	0.26	0.029 (4.8)	0.12	0.38	0.34 (0.9)	0.44	0.22	0.035 (4.4)	0.18
rs3928306	3010	A/G	0.39	0.37	0.40	0.32	1.36	0.14 (2.2)	0.29	1.23	0.52 (0.4)	0.60	1.39	0.13 (2.3)	0.33
rs200999343	3206	A/G	0.11	0.12	0.10	0.051	2.26	0.033 (4.5)	0.13	2.49	0.083 (3.0)	0.15	2.19	0.051 (3.8)	0.21
rs2853516	3316	A/G	0.014	0.020	0.012	0.010	1.34	0.75 (0.1)	0.82	1.95	0.58 (0.3)	0.65	1.15	0.89 (< 0.1)	0.93
rs41460449	3394	G/A	0.023	0.039	0.018	0.021	1.10	0.88 (< 0.1)	0.92	1.92	0.45 (0.6)	0.54	0.86	0.84 (< 0.1)	0.90
rs201212638	3398	G/A	0.018	-	-	0	-	0.058 (3.6)	0.17	-	-	-	-	-	-
rs200319905	3497	A/G	0.046	0.040	0.047	0.041	1.13	0.80 (0.1)	0.86	0.98	0.98 (< 0.1)	0.99	1.17	0.75 (0.1)	0.84
rs3021088	5460	A/G	0.045	0.059	0.041	0.071	0.62	0.25 (1.3)	0.41	0.82	0.76 (0.1)	0.80	0.56	0.21 (1.5)	0.43
rs200165736	6253	G/A	0.022	0.039	0.017	0.005	4.50	0.13 (2.2)	0.28	8.00	0.047 (4.0)	0.10	3.48	0.25 (1.3)	0.47
rs28358884	8414	A/G	0.39	0.37	0.40	0.32	1.36	0.13 (2.3)	0.28	1.26	0.48 (0.5)	0.56	1.39	0.13 (2.3)	0.33
rs201336180	8684	A/G	0.009	0.020	-	0.010	0.88	0.90 (< 0.1)	0.93	1.95	0.58 (0.3)	0.65	-	-	-
rs2000975	8701	A/G	0.34	0.37	0.33	0.40	0.76	0.18 (1.8)	0.34	0.89	0.71 (0.1)	0.76	0.73	0.14 (2.1)	0.35
rs199646902	9053	A/G	0.009	0	0.012	0.015	0.59	0.56 (0.3)	0.68	0	0.38 (0.8)	0.47	0.77	0.78 (0.1)	0.86
rs201397417	10,345	G/A	0.036	0.059	0.029	0.061	0.57	0.23 (1.4)	0.39	0.96	0.96 (< 0.1)	0.96	0.46	0.15 (2.1)	0.35
rs2853826	10,398	A/G	0.29	0.30	0.29	0.32	0.90	0.61 (0.3)	0.71	0.92	0.81 (0.1)	0.84	0.89	0.61 (0.3)	0.74
rs200478835	10,410	G/A	0.099	0.12	0.093	0.030	3.48	5.17 × 10 ^− 3 (7.8)	0.045	4.24	9.70 × 10 ^− 3 (6.7)	0.034	3.27	0.011 (6.4)	0.11
rs200487531	10,609	G/A	0.040	0.039	0.041	0.051	0.79	0.61 (0.3)	0.71	0.76	0.73 (0.1)	0.78	0.79	0.65 (0.2)	0.77
rs200873900	11,696	A/G	0.013	0	0.017	0.025	0.52	0.37 (0.8)	0.52	0	0.25 (1.3)	0.35	0.68	0.60 (0.3)	0.74
rs28359169	11,969	A/G	0.013	-	-	0.005	2.67	0.38 (0.8)	0.53	-	-	-	-	-	-
rs2853501	13,105	G/A	0.014	0.020	0.012	0.036	0.37	0.14 (2.2)	0.29	0.54	0.56 (0.3)	0.63	0.32	0.14 (2.2)	0.34
rs200044200	13,135	A/G	-	0.059	-	0	-	-	-	-	6.15 × 10 ^− 4 (11.7)	4.9 × 10 ^− 3	-	-	-
rs28359178	13,708	A/G	0.036	0.078	0.023	0.005	7.29	0.030 (4.7)	0.12	16.68	8.94 × 10 ^− 4 (11.0)	6.4 × 10 ^− 3	4.67	0.13 (2.3)	0.34
rs200657506	13,942	G/A	0.013	0.039	0.006	0.015	0.88	0.88 (< 0.1)	0.91	2.64	0.28 (1.2)	0.37	0.38	0.38 (0.8)	0.58
rs28357671	14,178	G/A	0.004	0	0.006	0.020	0.22	0.14 (2.2)	0.28	0	0.30 (1.1)	0.40	0.28	0.23 (1.4)	0.44
rs201551481	14,927	G/A	0.018	0.020	0.017	0.015	1.18	0.83 (< 0.1)	0.88	1.29	0.82 (< 0.1)	0.86	1.15	0.87 (< 0.1)	0.91
rs200786872	14,979	G/A	0.11	0.12	0.10	0.051	2.26	0.033 (4.5)	0.13	2.49	0.083 (3.0)	0.15	2.19	0.051 (3.8)	0.21
rs2853506	15,218	G/A	0.014	0	0.018	0.016	0.87	0.87 (< 0.1)	0.90	0	0.37 (0.8)	0.47	1.13	0.88 (< 0.1)	0.92
rs201250154	15,236	G/A	0.013	0.020	0.012	0.051	0.25	0.027 (4.9)	0.11	0.37	0.33 (0.9)	0.43	0.22	0.034 (4.5)	0.18
rs527236176	15,314	A/G	0.022	0.039	-	0.010	2.24	0.33 (1)	0.48	3.98	0.14 (2.2)	0.23	-	-	-
rs527236177	15,323	A/G	0.036	0.039	0.035	0.046	0.78	0.61 (0.3)	0.71	0.85	0.84 (< 0.1)	0.87	0.76	0.60 (0.3)	0.74
rs199951903	15,497	A/G	0.041	0.039	0.041	0.046	0.88	0.79 (0.1)	0.85	0.85	0.84 (< 0.1)	0.87	0.89	0.82 (0.1)	0.88
rs527236193	15,758	G/A	0.009	0	0.012	0.015	0.59	0.56 (0.3)	0.67	0	0.38 (0.8)	0.47	0.76	0.77 (0.1)	0.85
rs201023973	15,860	G/A	0.036	0.039	0.035	0.041	0.88	0.8 (0.1)	0.86	0.96	0.96 (< 0.1)	0.97	0.85	0.77 (0.1)	0.85
rs193303003	15,941	G/A	0.018	0.020	0.017	0.020	0.88	0.86 (< 0.1)	0.90	0.97	0.97 (< 0.1)	0.98	0.86	0.84 (< 0.1)	0.90
rs41378955	16,390	A/G	0.040	0.059	0.035	0.015	2.72	0.12 (2.4)	0.27	4.04	0.071 (3.3)	0.14	2.34	0.22 (1.5)	0.44

MAF, minor allele frequency; BP, biological position; OR, odds ratio; PSY, psychotic disorder; BD, bipolar disorder; SZ, schizophrenia
The reference genome sequence is GRCh38/hg38. P_uncorr values < 0.05 are shown in boldface. P_GC values < 0.05 are shown in boldface and underlined

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