Bipolar | Control | |
---|---|---|
N | 85 | 44 |
Age, median (Q1; Q3) | 33 (26; 42) | 30.5 (24; 40.5) |
Female; N (%) | 41 (48.2) | 19 (43.2) |
Years of education, median (Q1; Q3) | 14 (12; 17) | 15 (13; 17) |
Smokers; N (%) | 29 (34.1) | 8 (18.2) |
Alcohol Consumption, median (Q1; Q3) | 0.2 (0; 1) | 0.5 (0;1) |
Lithium, N (%) | 44 (51.8) | 0 |
Antipsychotics, N (%) | 35 (41.2) | 0 |
Anticonvulsants, N (%) | 42 (49.4) | 0 |
CSF-Aβ42 (pg/ml) | 603 (173.91) [25(29.41%)] | 631.82 (157.44) [6(13.64%)] |
CSF-Aβ40 (pg/ml) | 5697.42 (1571.93) [25(29.41%)] | 5888.55 (1340.25) [6(13.64%)] |
CSF-Aβ38 (pg/ml) | 2224 (663.88) [25(29.41%)] | 2291.71 (589.32) [6(13.64%)] |
CSF-Aβ42/40 ratio | 0.11 (0.01) [25(29.41%)] | 0.11 (0.01) [6(13.64%)] |
CSF-Aβ42/38 ratio | 0.27 (0.02) [25(29.41%)] | 0.28 (0.02) [6(13.64%)] |
CSF-sAPPα (ng/ml) | 272.03 (109.68) [25(29.41%)] | 295.76 (112.29) [6(13.64%)] |
CSF-aAPPβ (ng/ml) | 571.32 (191.44) [25(29.41%)] | 596.84 (207.44) [6(13.64%)] |
CSF-Total Tau (pg/ml) | 205.3 (82.05) [25(29.41%)] | 195.61 (73.25) [6(13.64%)] |
CSF-Phosphyrolated Tau (pg/ml) | 33.86 (9.79) [25(29.41%)] | 33.21 (8.94) [6(13.64%)] |
CSF- Total Tau/phosphorylated Taua | 0.17 (0.15; 0.18) [26(30.59%)] | 0.17 (0.15; 0.18) [6(13.64%)] |
CSF_Neurogranin (pg/ml)a | 167.5 (139.25; 191.75) [25(29.41%)] | 171 (125.75; 216.25) [6(13.64%)] |
CSF-Neurofilament Light Chain (pg/ml)a | 336.5 (246.5; 490.5) [25(29.41%)] | 354.5 (214.75; 566.75) [6(13.64%)] |
Plasma-Aβ42 (pg/ml) | 10.77 (2.45) [4(4.71%)] | 10.17 (2.15) [1(2.27%)] |
Plasma-Aβ40 (pg/ml) | 225.93 (57.87) [3(3.53%)] | 215.58 (51.64) [1(2.27%)] |
Plasma-Aβ42/40 ratio | 0.05 (0.01) [4(4.71%)] | 0.05 (0.01) [1(2.27%)] |
Plasma-total Tau (pg/ml) | 3.03 (0.95) [3(3.53%)] | 2.82 (0.88) [1(2.27%)] |
Plasma-Neurofilament Light Chain (pg/ml)a | 6.87 (4.98; 9.11) [5(5.88%)] | 5.73 (4.5; 7.84) [1(2.27%)] |
Serum-S100 (µg/ml) (pg/ml)a | 0.04 (0.03; 0.05) [4(4.71%)] | 0.04 (0.03; 0.05) [1(2.27%)] |
Global cognition | − 0.24 (0.61) [0(0%)] | − 0.01 (0.51) [0(0%)] |
Verbal memory | − 0.22 (0.75) [0(0%)] | 0 (0.66) [1 (2.27%)] |
Executive function | − 0.18 (0.69) [2(2.35%)] | − 0.01 (0.67) [1(2.27%)] |
Psychomotor speed | − 0.39 (0.89) [0(0%)] | − 0.02 (0.86) [2(4.55%)] |
Sustained attention | − 0.19 (1) [6(7.06%)] | 0 (0.91) [1(2.27%)] |