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Table 2 Treatments in the last 12 months and baseline status between RCBD and NRCBD. Significance with Bonferroni correction requires p < 0.0012 (0.05/41)

From: Sociodemographic, clinical and treatment characteristics of current rapid-cycling bipolar disorder: a multicenter Chinese study

Variables

Total (n = 520)

RCBD (n = 49)

NRCBD n = 471)

t/Z/χ2

P

Number of psychotropic medications

   

-

0.7004

 No medication

10(1.92)

1(2.04)

2(1.91)

  

 One medication

15(2.88)

1(2.04)

14(2.97)

  

 Two medications

89(17.12)

11(22.45)

78(16.56)

  

 Three and more medications

406(78.08)

36(73.47)

370(78.56)

  

 Mood stabilizers

476(91.5)

46(93.9)

430(91.3)

-

0.7869

 Lithium

270(51.9)

24(49.0)

246(52.2)

0.1878

0.6648

 Valproic acid

319(61.4)

32(65.3)

287(60.9)

0.3578

0.5498

 Carbamazepine

1(0.2)

0(0.0)

1(0.2)

-

1.0000

 Lamotrigine

44(8.5)

8(16.3)

36(7.6)

-

0.0539

Number of mood stabilizers

   

-

0.3246

 One mood stabilizer

325(62.5)

30(61.2)

295(62.6)

  

 Two mood stabilizers

144(27.7)

14(28.6)

130(27.6)

  

 Three mood stabilizers

7(1.4)

2(4.1)

5(1.1)

  

 Antipsychotics

440(84.62)

41(83.67)

399(84.71)

0.0369

0.8477

 Antidepressants

206(39.62)

22(44.90)

184(39.07)

0.6311

0.4270

 Benzodiazepines

93(17.88)

10(20.41)

83(17.62)

0.2346

0.6281

 ECT during hospitalization in the last 12 months (n = 348)

98(28.2)

3(11.1)

95(29.6)

4.2060

0.0403

 MDQ Part 1 scores (Mean ± SE)

3.13 ± 3.19

3.92 ± 2.93

3.04 ± 3.21

5.5477

0.0105

 QIDS-SR16 score (Mean ± SE)

7.75 ± 5.47

9.10 ± 5.05

7.60 ± 5.49

5.1690

0.0230

  1. bolded to represent p values less than 0.05.BD bipolar disorder; RCBD rapid cycling bipolar disorder; NRCBD non-rapid cycling bipolar disorder; ECT electroconvulsive therapy; MDQ Mood Disorder Questionnaire; QIDS-SR16 Brief 16-item Quick Inventory of Depressive Symptomatology Self-Report