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  1. Research

    Current irritability associated with hastened depressive recurrence and delayed depressive recovery in bipolar disorder

    Current irritability is associated with greater retrospective and current bipolar disorder (BD) illness severity; less is known about prospective longitudinal implications of current irritability. We examined ...

    Laura D. Yuen, Saloni Shah, Dennis Do, Shefali Miller, Po W. Wang, Farnaz Hooshmand and Terence A. Ketter

    International Journal of Bipolar Disorders 2016 4:15

    Published on: 30 July 2016

  2. Research

    Does CRP predict outcome in bipolar disorder in regular outpatient care?

    The association between inflammation and the course of mood disorders is receiving increased attention. This study aims to investigate whether a sub-group of patients with BD can be identified for which a high...

    Sonya M. Balukova, Bartholomeus C. M. Haarman, Rixt F. Riemersma-van der Lek and Robert A. Schoevers

    International Journal of Bipolar Disorders 2016 4:14

    Published on: 18 July 2016

  3. Research

    Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study

    Genetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem disorder in which immune dysfunction and infectious insults seem to play a major role in ...

    José Oliveira, Rémi Kazma, Edith Le Floch, Meriem Bennabi, Nora Hamdani, Djaouida Bengoufa, Mehdi Dahoun, Céline Manier, Frank Bellivier, Rajagopal Krishnamoorthy, Jean-François Deleuze, Robert Yolken, Marion Leboyer and Ryad Tamouza

    International Journal of Bipolar Disorders 2016 4:11

    Published on: 20 May 2016

  4. Review

    Big data for bipolar disorder

    The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big da...

    Scott Monteith, Tasha Glenn, John Geddes, Peter C. Whybrow and Michael Bauer

    International Journal of Bipolar Disorders 2016 4:10

    Published on: 11 April 2016

  5. Research

    The direct and indirect effects of lurasidone monotherapy on functional improvement among patients with bipolar depression: results from a randomized placebo-controlled trial

    Bipolar depression is characterized by depressive symptoms and impairment in many areas of functioning, including work, family, and social life. The objective of this study was to assess the independent, direc...

    Krithika Rajagopalan, Elizabeth Dansie Bacci, Kathleen W. Wyrwich, Andrei Pikalov and Antony Loebel

    International Journal of Bipolar Disorders 2016 4:7

    Published on: 16 March 2016

  6. Research

    Development and validation of the BD SX: a brief measure of mood and symptom variability for use with adults with bipolar disorder

    Ecological momentary sampling in BD research requires brief symptom measures with low cognitive demands to maximize data collection across the range of BD symptomatology. We developed the BD Sx cognizant of the c...

    Norm O’Rourke, Andrew Sixsmith, David B. King, Hamed Yaghoubi-Shahir and Sarah L. Canham

    International Journal of Bipolar Disorders 2016 4:8

    Published on: 1 March 2016

  7. Review

    Behavioral and emotional adverse events of drugs frequently used in the treatment of bipolar disorders: clinical and theoretical implications

    Behavioral and emotional adverse events induced by drugs commonly prescribed to patients with bipolar disorders are of paramount importance to clinical practice and research. However, no reviews on the topic h...

    Alejandro Szmulewicz, Cecilia Samamé, Pablo Caravotta, Diego J. Martino, Ana Igoa, Diego Hidalgo-Mazzei, Francesc Colom and Sergio A. Strejilevich

    International Journal of Bipolar Disorders 2016 4:6

    Published on: 16 February 2016

  8. Review

    Bipolar disorder and antithyroid antibodies: review and case series

    Mood disorders and circulating thyroid antibodies are very prevalent in the population and their concomitant occurrence may be due to chance. However, thyroid antibodies have been repeatedly hypothesized to p...

    Alberto Bocchetta, Francesco Traccis, Enrica Mosca, Alessandra Serra, Giorgio Tamburini and Andrea Loviselli

    International Journal of Bipolar Disorders 2016 4:5

    Published on: 11 February 2016

  9. Guidelines

    Harnessing the potential of community-based participatory research approaches in bipolar disorder

    Despite the rapid growth in the sophistication of research on bipolar disorder (BD), the field faces challenges in improving quality of life (QoL) and symptom outcomes, adapting treatments for marginalized com...

    Erin E. Michalak, Steven Jones, Fiona Lobban, Guillermo Perez Algorta, Steven J. Barnes, Lesley Berk, Michael Berk, Rachelle Hole, Sara Lapsley, Victoria Maxwell, Roumen Milev, John McManamy, Greg Murray, Mauricio Tohen, Samson Tse, Manuel Sanchez de Carmona…

    International Journal of Bipolar Disorders 2016 4:4

    Published on: 9 February 2016

  10. Research

    Circadian rhythmicity in emerging mood disorders: state or trait marker?

    Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young peo...

    Ashlee B. Grierson, Ian B. Hickie, Sharon L. Naismith, Daniel F. Hermens, Elizabeth M. Scott and Jan Scott

    International Journal of Bipolar Disorders 2016 4:3

    Published on: 13 January 2016

  11. Review

    The role of childhood trauma in bipolar disorders

    This review will discuss the role of childhood trauma in bipolar disorders. Relevant studies were identified via Medline (PubMed) and PsycINFO databases published up to and including July 2015. This review con...

    Monica Aas, Chantal Henry, Ole A. Andreassen, Frank Bellivier, Ingrid Melle and Bruno Etain

    International Journal of Bipolar Disorders 2016 4:2

    Published on: 13 January 2016

  12. Letter to the Editor

    Lithium overdosage and related tests

    Lithium acts biochemically through the inositol depletion in brain cortex. At low doses, however, it is partly effective and/or ineffective, whereas in high concentrations is toxic. We would like to make one p...

    Paolo D. Pigatto, Bernardo Dell’Osso and Gianpaolo Guzzi

    International Journal of Bipolar Disorders 2016 4:1

    Published on: 12 January 2016

  13. Short communication

    Will mania survive DSM-5 and ICD-11?

    As a natural phenomenon, mania without major depression will of course survive DSM-5 and ICD-11, but following its integration as a diagnosis into bipolar-I disorder (BP-I) in those manuals, BP-I will be more ...

    Jules Angst

    International Journal of Bipolar Disorders 2015 3:24

    Published on: 9 December 2015

  14. Review

    Treatment of lithium intoxication: facing the need for evidence

    Lithium has been used as the gold standard in the treatment of major depressive and bipolar disorders for decades. Due to its narrow therapeutic index, lithium toxicity is a common clinical problem. Although r...

    R. Haussmann, M. Bauer, S. von Bonin, P. Grof and U. Lewitzka

    International Journal of Bipolar Disorders 2015 3:23

    Published on: 22 October 2015

  15. Research

    Low self-recognition and awareness of past hypomanic and manic episodes in the general population

    Bipolar disorder is often underdiagnosed and undertreated. Its detection and correct diagnosis highly relies on the report of past hypomanic or manic episodes. We investigated the recognition and awareness of ...

    Eline J. Regeer, Ralph W. Kupka, Margreet ten Have, Wilma Vollebergh and Willem A. Nolen

    International Journal of Bipolar Disorders 2015 3:22

    Published on: 6 October 2015

  16. Review

    Big data are coming to psychiatry: a general introduction

    Big data are coming to the study of bipolar disorder and all of psychiatry. Data are coming from providers and payers (including EMR, imaging, insurance claims and pharmacy data), from omics (genomic, proteomi...

    Scott Monteith, Tasha Glenn, John Geddes and Michael Bauer

    International Journal of Bipolar Disorders 2015 3:21

    Published on: 29 September 2015

  17. Research

    Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments

    Some, but not all, prior investigations suggest armodafinil may have utility as an adjunctive treatment in bipolar I depression.

    Mark A Frye, Jess Amchin, Michael Bauer, Caleb Adler, Ronghua Yang and Terence A Ketter

    International Journal of Bipolar Disorders 2015 3:18

    Published on: 2 September 2015

  18. Research

    Symptom severity of bipolar disorder during the menopausal transition

    Little is known about the mood symptom experience of women with bipolar disorder during the menopausal transition (MT). Yet times of rapid hormonal decline, such as the postpartum, are associated with increase...

    Wendy K. Marsh, Bernice Gershenson and Anthony J. Rothschild

    International Journal of Bipolar Disorders 2015 3:17

    Published on: 22 August 2015

  19. Editorial

    Developmental staging models in bipolar disorder

    The previous contribution of Duffy and colleagues suggests that a chain of behavioral events starting during childhood precedes the development of full-blown bipolar disorder. In this vein, the recent contribu...

    Ives C Passos, Karen Jansen and Flavio Kapczinski

    International Journal of Bipolar Disorders 2015 3:16

    Published on: 31 July 2015

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