Articles
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Citation: International Journal of Bipolar Disorders 2015 3:19
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Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments
Some, but not all, prior investigations suggest armodafinil may have utility as an adjunctive treatment in bipolar I depression.
Citation: International Journal of Bipolar Disorders 2015 3:18 -
Symptom severity of bipolar disorder during the menopausal transition
Little is known about the mood symptom experience of women with bipolar disorder during the menopausal transition (MT). Yet times of rapid hormonal decline, such as the postpartum, are associated with increase...
Citation: International Journal of Bipolar Disorders 2015 3:17 -
Developmental staging models in bipolar disorder
The previous contribution of Duffy and colleagues suggests that a chain of behavioral events starting during childhood precedes the development of full-blown bipolar disorder. In this vein, the recent contribu...
Citation: International Journal of Bipolar Disorders 2015 3:16 -
The suicide prevention effect of lithium: more than 20 years of evidence—a narrative review
The management and treatment of patients with suicidal behavior is one of the most challenging tasks for health-care professionals. Patients with affective disorders are at high risk for suicidal behavior, the...
Citation: International Journal of Bipolar Disorders 2015 3:15 -
Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses
We aimed to establish a bipolar disorder biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and resear...
Citation: International Journal of Bipolar Disorders 2015 3:14 -
Lithium nephrotoxicity
Reports of toxic effects on the kidney of lithium treatment emerged very soon after lithium therapy was introduced. Lithium-induced nephrogenic diabetes insipidus is usually self-limiting or not clinically dan...
Citation: International Journal of Bipolar Disorders 2015 3:13 -
Common use of dietary supplements for bipolar disorder: a naturalistic, self-reported study
Dietary supplements are taken by about half of Americans. Knowledge of dietary supplement use is important because they may interact with prescription drugs or other supplements, cause adverse reactions includ...
Citation: International Journal of Bipolar Disorders 2015 3:12 -
Patterns of response to aripiprazole, lithium, haloperidol, and placebo across factor scores of mania
A previous factor analysis of Young Mania Rating Scale and Montgomery-Åsberg Depression Rating Scale items identified composite factors of depression, mania, sleep disturbance, judgment/impulsivity, and irrita...
Citation: International Journal of Bipolar Disorders 2015 3:11 -
Validity and reliability of the Finnish version of the Functioning Assessment Short Test (FAST) in bipolar disorder
The Functioning Assessment Short Test (FAST) was developed for the clinical evaluation of functional impairment of patients suffering from bipolar disorder. The aim of this study was to validate the Finnish ve...
Citation: International Journal of Bipolar Disorders 2015 3:10 -
Cognitive impairment in first-episode mania: a systematic review of the evidence in the acute and remission phases of the illness
There is evidence of cognitive impairment that persists in the remission phase of bipolar disorder; however, the extent of the deficits that occur from the first onset of the disorder remains unclear. This is ...
Citation: International Journal of Bipolar Disorders 2015 3:9 -
Clinical characteristics of bipolar disorder: a comparative study between Argentina and the United States
Bipolar disorder presents with diverse clinical manifestations. Numerous investigators have sought to identify variables that may predict a more severe illness course.
Citation: International Journal of Bipolar Disorders 2015 3:8 -
Who will benefit from antidepressants in the acute treatment of bipolar depression? A reanalysis of the STEP-BD study by Sachs et al. 2007, using Q-learning
There is substantial uncertainty regarding the efficacy of antidepressants in the treatment of bipolar disorders.
Citation: International Journal of Bipolar Disorders 2015 3:7 -
The influence of life events on first and recurrent admissions in bipolar disorder
Life events play an important role in the onset and course of bipolar disorder. We will test the influence of life events on first and recurrent admissions in bipolar disorder and their interaction to test the...
Citation: International Journal of Bipolar Disorders 2015 3:6 -
Multi-state models for investigating possible stages leading to bipolar disorder
It has been proposed that bipolar disorder onsets in a predictable progressive sequence of clinical stages. However, there is some debate in regard to a statistical approach to test this hypothesis. The object...
Citation: International Journal of Bipolar Disorders 2015 3:5 -
Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report
There is an increasing use of ayahuasca for recreational purposes. Furthermore, there is a growing evidence for the antidepressant properties of its components. However, there are no reports on the effects of ...
Citation: International Journal of Bipolar Disorders 2015 3:4 -
Impact of childhood trauma and affective temperament on resilience in bipolar disorder
The aim of this study was to investigate whether childhood trauma (CT) and affective temperament have an impact on resilience in bipolar patients.
Citation: International Journal of Bipolar Disorders 2015 3:3 -
Burden, reward, and coping of adult offspring of patients with depression and bipolar disorder
In previous years, research has focused on the situation of psychiatric patients' minor children. The aims of this qualitative study were to describe the experience of adult children of depressed and bipolar p...
Citation: International Journal of Bipolar Disorders 2015 3:2 -
More robust evidence for the efficacy of lithium in the long-term treatment of bipolar disorder: should lithium (again) be recommended as the single preferred first-line treatment?
With two recent systematic reviews and meta-analyses on the efficacy of lithium compared to placebo and other treatment options, it can now be concluded that lithium is the only drug that has been shown effica...
Citation: International Journal of Bipolar Disorders 2015 3:1 -
Prophylactic lithium treatment and cognitive performance in patients with a long history of bipolar illness: no simple answers in complex disease-treatment interplay
Cognitive impairment in patients with bipolar disorder (BD) is not restricted to symptomatic phases. It is also present in euthymia. There is evidence of differences in the brain’s structure between bipolar pa...
Citation: International Journal of Bipolar Disorders 2014 2:16 -
Lithium for prevention of mood episodes in bipolar disorders: systematic review and meta-analysis
In a previous meta-analysis of randomized controlled trials comparing lithium with placebo as a long-term treatment in bipolar disorders, we observed a clear preventative effect for manic episodes; however, th...
Citation: International Journal of Bipolar Disorders 2014 2:15 -
Lithium as add-on to quetiapine XR in adult patients with acute mania: a 6-week, multicenter, double-blind, randomized, placebo-controlled study
Quetiapine extended release (XR) and lithium are treatments with proven efficacy in acute mania. This randomized study evaluated the efficacy and safety of lithium or placebo as add-on to quetiapine XR in adul...
Citation: International Journal of Bipolar Disorders 2014 2:14 -
Every reason to discontinue lithium
Lithium as a gold standard therapy for bipolar disorder is well known to have a number of medical comorbidities that impact renal, parathyroid, and thyroid function. Despite these medical comorbidities, there ...
Citation: International Journal of Bipolar Disorders 2014 2:12 -
Compliance as a stable function in the treatment course of bipolar disorder in patients stabilized on olanzapine: results from a 24-month observational study
Compliance is a key factor in the maintenance treatment of bipolar disorder. This noninterventional study was conducted to explore factors associated with higher levels of compliance in bipolar patients, all t...
Citation: International Journal of Bipolar Disorders 2014 2:13 -
Are rates of pediatric bipolar disorder increasing? Results from a nationwide register study
Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it i...
Citation: International Journal of Bipolar Disorders 2014 2:10 -
Mood dynamics in bipolar disorder
The nature of mood variation in bipolar disorder has been the subject of relatively little research because detailed time series data has been difficult to obtain until recently. However some papers have addre...
Citation: International Journal of Bipolar Disorders 2014 2:11 -
Letter to the editor: is it valid to break down results from long-term trials in bipolar disorder by polarity of relapses?
When analysing and reporting data from long-term drug trials in bipolar disorder, it has become the standard to break down the outcome into the prevention of mania and the prevention of depression. However, as...
Citation: International Journal of Bipolar Disorders 2014 2:8 -
Mood regulation in bipolar disorders viewed through the pendulum dynamics concept
Bipolar disorders have been characterized by powerful fluctuations of energy, mood, and thinking patterns. Mood episodes (manic or depressive) could be considered as deviations of a psycho-physiological index ...
Citation: International Journal of Bipolar Disorders 2014 2:9 -
Lateral hypothalamic kindling induces manic-like behavior in rats: a novel animal model
The lateral hypothalamus integrates critical physiological functions such as the sleep-wake cycle, energy expenditure, and sexual behaviors. These functions are severely dysregulated during mania. In this stud...
Citation: International Journal of Bipolar Disorders 2014 2:7 -
Are renal tumors associated with lithium treatment?
Citation: International Journal of Bipolar Disorders 2014 2:6 -
Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of ...
Citation: International Journal of Bipolar Disorders 2014 2:5 -
Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder
Bipolar disorder is a highly heritable illness that onsets in adolescence and young adulthood. We examined gene expression (mRNA) and protein levels of candidate immune and neurotrophic markers in well-charact...
Citation: International Journal of Bipolar Disorders 2014 2:4 -
The impact of treatment decisions on the diagnosis of bipolar disorders
Citation: International Journal of Bipolar Disorders 2014 2:3 -
Impulsivity: present during euthymia in bipolar disorder? - a systematic review
Because impulsivity is part of the presentation of bipolar disorder (BD) and is associated with its course, this systematic review presents the evidence whether increased impulsivity is present in a stable, eu...
Citation: International Journal of Bipolar Disorders 2014 2:2 -
Using theatre to address mental illness stigma: a knowledge translation study in bipolar disorder
Reduction of the stigma of mental illness is an international priority; arts- and contact-based approaches represent a promising mode of intervention. This project was designed to explore the impact of a one-w...
Citation: International Journal of Bipolar Disorders 2014 2:1 -
Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder
Bipolar disorder (BD) is a complex psychiatric phenotype with a high heritability and a multifactorial etiology. Multisite collaborative efforts using genome-wide association studies (GWAS) have identified onl...
Citation: International Journal of Bipolar Disorders 2013 1:28 -
Behavioral addictions in euthymic patients with bipolar I disorder: a comparison to controls
Bipolar disorder may be associated with a hypersensitive behavioral approach system and therefore to increased reward sensitivity. The objective of this study is to explore the interrelationships between bipol...
Citation: International Journal of Bipolar Disorders 2013 1:27 -
Antidepressant dosage taken by patients with bipolar disorder: factors associated with irregularity
This study analyzed regularity in the daily dosage of antidepressants taken by patients with bipolar disorder and identified the factors associated with irregularity.
Citation: International Journal of Bipolar Disorders 2013 1:26 -
Occurrence of bipolar spectrum disorder and comorbidities in women with eating disorders
Eating disorder (ED) patients often have comorbidities with other psychiatric disorders, especially with mood disorders. Although recent studies suggest an intimate relationship between ED and bipolar disorder...
Citation: International Journal of Bipolar Disorders 2013 1:25 -
Nutrition, Exercise, and Wellness Treatment in bipolar disorder: proof of concept for a consolidated intervention
This pilot study examines the proof of concept of a consolidated Nutrition, Exercise, and Wellness Treatment (NEW Tx) for overweight individuals with bipolar disorder.
Citation: International Journal of Bipolar Disorders 2013 1:24 -
Distress and disability in young adults presenting to clinical services with mood disorders
Distress and/or dysfunction are well established as key reasons for help-seeking. We explore the characteristics of groups defined by high or low distress or disability in young people with unipolar depression...
Citation: International Journal of Bipolar Disorders 2013 1:23 -
Searching the internet for health information about bipolar disorder: some cautionary issues
Adults routinely use the Internet as a source of health information. Patients with bipolar disorder and caregivers should be encouraged to increase their knowledge of this complex illness, including through th...
Citation: International Journal of Bipolar Disorders 2013 1:22 -
Evaluating depressive symptoms in hypomanic and manic episodes using a structured diagnostic tool: validation of a new Mini International Neuropsychiatric Interview (M.I.N.I.) module for the DSM-5 'With Mixed Features’ specifier
The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), includes a new 'With Mixed Features’ specifier for mood episodes. In (hypo-)manic episodes, the specifier is given if three or ...
Citation: International Journal of Bipolar Disorders 2013 1:21 -
Transitions: Athanasios Koukopoulos [AθανάσιΟς κΟυκόπΟυλΟς], M.D. (1931–2013)
Citation: International Journal of Bipolar Disorders 2013 1:17 -
Glial-specific gene alterations associated with manic behaviors
Glial dysfunction has been purported to be important to the pathophysiology of bipolar illness. However, manic behavior has not been previously demonstrated to result as a consequence of glial pathology. The a...
Citation: International Journal of Bipolar Disorders 2013 1:20 -
The common bipolar phenotype in young people
Mood elevation is common in adolescents and young adults. The aim of this study was to investigate the prevalence of a bipolar diagnosis and co-morbidity in individuals identified by online screening for exper...
Citation: International Journal of Bipolar Disorders 2013 1:19 -
Hypercalcemia in patients with bipolar disorder treated with lithium: a cross-sectional study
Lithium-induced hyperparathyroidism (LIH) is a relative underrecognized complication of long-term lithium treatment. Hypercalcemia may be the first, but often overlooked, sign of LIH. Symptoms of LIH can be si...
Citation: International Journal of Bipolar Disorders 2013 1:18 -
Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events
Poor sleep quality is known to precede the onset of mood episodes and to be associated with poor treatment outcomes in bipolar disorder (BD). We sought to identify modifiable factors that correlate with poor s...
Citation: International Journal of Bipolar Disorders 2013 1:16 -
Bipolar disorder with comorbid anxiety disorders: impact of comorbidity on treatment outcome in cognitive-behavioral therapy and psychoeducation
Comorbid anxiety disorders are extremely prevalent in bipolar disorder (BD) and have substantial impact on the course of illness. Limited evidence regarding treatment factors has led to a renewal of research e...
Citation: International Journal of Bipolar Disorders 2013 1:15 -
Bipolar disorders in DSM-5: strengths, problems and perspectives
The diagnostic classification of mood disorders by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) had two major shortcomings: an underdiagnosis of bipolar disorders and a large proportion o...
Citation: International Journal of Bipolar Disorders 2013 1:12
- ISSN: 2194-7511 (electronic)