Articles

Monitoring of patients treated with lithium for bipolar disorder: an international survey

Adequate monitoring of patients using lithium is needed for optimal dosing and for early identification of patients with (potential) ADEs. The objective was to internationally assess how health care profession...

Authors: M. Nederlof, E. R. Heerdink, A. C. G. Egberts, I. Wilting, L. J. Stoker, R. Hoekstra and R. W. Kupka

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol)

Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depres...

Authors: Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi and Connie Thuroee Nielsen

Control charts for monitoring mood stability as a predictor of severe episodes in patients with bipolar disorder

Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an importan...

Authors: Maria D. L. A. Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders and John R. Geddes

Actigraphy as an objective intra-individual marker of activity patterns in acute-phase bipolar disorder: a case series

Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of (hyp...

Authors: Karoline Krane-Gartiser, Andreas Asheim, Ole Bernt Fasmer, Gunnar Morken, Arne E. Vaaler and Jan Scott

Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study

Concerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a c...

Authors: Alberto Bocchetta, Luca Ambrosiani, Gioia Baggiani, Claudia Pisanu, Caterina Chillotti, Raffaella Ardau, Fernanda Velluzzi, Doloretta Piras, Andrea Loviselli and Antonello Pani

The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study

Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused ...

Authors: Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi and Andres Alvarado

Resilience concepts in psychiatry demonstrated with bipolar disorder

The term resilience describes stress–response patterns of subjects across scientific disciplines. In ecology, advances have been made to clearly distinguish resilience definitions based on underlying mechanist...

Authors: David G. Angeler, Craig R. Allen and Maj-Liz Persson

Smartphone-based objective monitoring in bipolar disorder: status and considerations

In 2001, the WHO stated that: “The use of mobile and wireless technologies to support the achievement of health objectives (mHealth) has the potential to transform the face of health service delivery across th...

Authors: Maria Faurholt-Jepsen, Michael Bauer and Lars Vedel Kessing

Association between CRP genetic diversity and bipolar disorder comorbid complications

Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute ph...

Authors: Wahid Boukouaci, José Oliveira, Bruno Etain, Meriem Bennabi, Christina Mariaselvam, Nora Hamdani, Céline Manier, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer and Ryad Tamouza

Interrater reliability in bipolar disorder research: current practices and suggestions for enhancing best practices

Authors: June Gruber and Lauren M. Weinstock

Cognitive functioning following stabilisation from first episode mania

The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group.

Authors: Rothanthi Daglas, Kelly Allott, Murat Yücel, Lisa P. Henry, Craig A. Macneil, Melissa K. Hasty, Michael Berk and Sue M. Cotton

Mentalization deficit in bipolar patients during an acute depressive and manic episode: association with cognitive functions

A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective ...

Authors: Anna Bodnar and Janusz K. Rybakowski

The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations

Relatively little is known about the onset of bipolar disorder, yet the early illness course is already associated with significant morbidity and mortality. Therefore, characterizing the bipolar illness trajec...

Authors: A. Duffy, C. Vandeleur, N. Heffer and M. Preisig

Anxiety, irritability, and agitation as indicators of bipolar mania with depressive symptoms: a post hoc analysis of two clinical trials

Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identif...

Authors: Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H. Young and Roger S. McIntyre

Animal models for bipolar disorder: from bedside to the cage

Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting o...

Authors: Dominik K. E. Beyer and Nadja Freund

Does perfectionism in bipolar disorder pedigrees mediate associations between anxiety/stress and mood symptoms?

Bipolar disorder (BD) and the anxiety disorders are highly comorbid. The present study sought to examine perfectionism and goal attainment values as potential mechanisms of known associations between anxiety, ...

Authors: Justine Corry, Melissa Green, Gloria Roberts, Janice M. Fullerton, Peter R. Schofield and Philip B. Mitchell

The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder

Although bipolar disorder (BD) and borderline personality disorder (BPD) share clinical characteristics and frequently co-occur, their interrelationship is controversial. Especially, the differentiation of rap...

Authors: Georg Riemann, Nadine Weisscher, Robert M. Post, Lori Altshuler, Susan McElroy, Marc A. Frye, Paul E. Keck Jr., Gabriele S. Leverich, Trisha Suppes, Heinz Grunze, Willem A. Nolen and Ralph W. Kupka

Erratum to: Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study

In the original version of this article (Wu et al. 2017), published on 1 September 2017, the name of author ‘Bo Cao’ was wrongly displayed. In this Erratum the incorrect name and correct name are shown. The origi...

Authors: Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares and Jair C. Soares

Childhood maltreatment and the medical morbidity in bipolar disorder: a case–control study

Childhood maltreatment (abuse and neglect) can have long-term deleterious consequences, including increased risk for medical and psychiatric illnesses, such as bipolar disorder in adulthood. Emerging evidence ...

Authors: Georgina M. Hosang, Helen L. Fisher, Rudolf Uher, Sarah Cohen-Woods, Barbara Maughan, Peter McGuffin and Anne E. Farmer

Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study

Bipolar disorder (BD) is a common disorder with high reoccurrence rate in general population. It is critical to have objective biomarkers to identify BD patients at an individual level. Neurocognitive signatur...

Authors: Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares and Jair C. Soares

Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups

Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO ...

Authors: Mirko Manchia, Giuseppe Maina, Bernardo Carpiniello, Federica Pinna, Luca Steardo, Virginia D’Ambrosio, Virginio Salvi, Martin Alda, Alfonso Tortorella and Umberto Albert

Lifetime eating disorder comorbidity associated with delayed depressive recovery in bipolar disorder

Although eating disorders (EDs) are common in bipolar disorder (BD), little is known regarding their longitudinal consequences. We assessed prevalence, clinical correlates, and longitudinal depressive severity...

Authors: Danielle R. Balzafiore, Natalie L. Rasgon, Laura D. Yuen, Saloni Shah, Hyun Kim, Kathryn C. Goffin, Shefali Miller, Po W. Wang and Terence A. Ketter

Online ethics: where will the interface of mental health and the internet lead us?

While e-health initiatives are poised to revolutionize delivery and access to mental health care, conducting clinical research online involves specific contextual and ethical considerations. Face-to-face psych...

Authors: Victoria Cosgrove, Emma Gliddon, Lesley Berk, David Grimm, Sue Lauder, Seetal Dodd, Michael Berk and Trisha Suppes

Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters

Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence of severe renal dysfunction; rate of dec...

Authors: Leonardo Tondo, Maria Abramowicz, Martin Alda, Michael Bauer, Alberto Bocchetta, Lorenza Bolzani, Cynthia V. Calkin, Caterina Chillotti, Diego Hidalgo-Mazzei, Mirko Manchia, Bruno Müller-Oerlinghausen, Andrea Murru, Giulio Perugi, Marco Pinna, Giuseppe Quaranta, Daniela Reginaldi…

Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study

The efficacy and utility of long-term prophylactic treatment in patients with bipolar disorders (BDs) have not been fully explored. This study aims to estimate the long-term clinical response of patients with ...

Authors: Sung Woo Ahn, Ji Hyun Baek, So-Yung Yang, Yongkang Kim, Youngah Cho, Yujin Choi, Kounseok Lee, Taesung Park and Kyung Sue Hong