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International Journal of Bipolar Disorders
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  1. Childhood trauma (CT) are frequently reported by patients with bipolar disorder (BD), but it is unclear whether and how CT contribute to patients’ cognitive and psychosocial impairments. We aimed to examine th...

    Authors: Kamilla Woznica Miskowiak, Katrine Bang Hansen, Johanna Mariegaard and Lars Vedel Kessing
    Citation: International Journal of Bipolar Disorders 2023 11:31
    Content type: Research Published on:

  2. For over half a century, it has been widely known that lithium is the most efficacious treatment for bipolar disorder. Yet, despite this, its prescription has consistently declined over this same period of tim...

    Authors: Gin S. Malhi, Erica Bell, Maedeh Jadidi, Michael Gitlin and Michael Bauer
    Citation: International Journal of Bipolar Disorders 2023 11:30
    Content type: Review Published on:

  4. We tested the hypothesis that, after initial improvement with intravenous ketamine in patients with bipolar disorder (BD) with severe depression and acute suicidal thinking or behavior, a fixed-dose combinatio...

    Authors: Andrew Nierenberg, Philip Lavin, Daniel C. Javitt, Richard Shelton, Michael T. Sapko, Sanjay Mathew, Robert E. Besthof and Jonathan C. Javitt
    Citation: International Journal of Bipolar Disorders 2023 11:28
    Content type: Research Published on:

  5. Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured...

    Authors: Craig Steel, Kim Wright, Guy M. Goodwin, Judit Simon, Nicola Morant, Rod S. Taylor, Michael Brown, Susie Jennings, Susie A. Hales, Jemma Regan, Michaela Sibsey, Zoe Thomas, Lynette Meredith and Emily A. Holmes
    Citation: International Journal of Bipolar Disorders 2023 11:27
    Content type: Research Published on:

  6. Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role. Some studies have investi...

    Authors: Ryobu Tachi, Kazutaka Ohi, Daisuke Nishizawa, Midori Soda, Daisuke Fujikane, Junko Hasegawa, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Shunsuke Sugiyama, Kiyoyuki Kitaichi, Ryota Hashimoto, Kazutaka Ikeda and Toshiki Shioiri
    Citation: International Journal of Bipolar Disorders 2023 11:26
    Content type: Research Published on:

  7. The distinction between bipolar I and bipolar II disorder and its treatment implications have been a matter of ongoing debate. The aim of this study was to examine differences between patients with bipolar I a...

    Authors: Giulio Emilio Brancati, Abraham Nunes, Katie Scott, Claire O’Donovan, Pablo Cervantes, Paul Grof and Martin Alda
    Citation: International Journal of Bipolar Disorders 2023 11:25
    Content type: Research Published on:

  8. Lithium is the preferred treatment for pregnant women with bipolar disorders (BD), as it is most effective in preventing postpartum relapse. Although it has been prescribed during pregnancy for decades, the sa...

    Authors: Noralie N. Schonewille, Pleun A. Terpstra, Maria E. N. van den Heuvel, Maria G. Van Pampus, Odile A. van den Heuvel and Birit F. P. Broekman
    Citation: International Journal of Bipolar Disorders 2023 11:24
    Content type: Research Published on:

  9. Evidence regarding the rate of relapse in people with bipolar disorder (BD), particularly from the UK, is lacking. This study aimed to evaluate the rate and associations of clinician-defined relapse over 5 yea...

    Authors: Danielle Hett, Isabel Morales-Muñoz, Buse Beril Durdurak, Max Carlish and Steven Marwaha
    Citation: International Journal of Bipolar Disorders 2023 11:23
    Content type: Research Published on:

  10. Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people l...

    Authors: Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kürsat AltınbaÅŸ, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars…
    Citation: International Journal of Bipolar Disorders 2023 11:22
    Content type: Research Published on:

  11. Rapid-cycling (RC; ≥ 4 episodes/year) in bipolar disorder (BD) has been recognized since the 1970s and associated with inferior treatment response. However, associations of single years of RC with overall cycl...

    Authors: Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu and Ross J. Baldessarini
    Citation: International Journal of Bipolar Disorders 2023 11:21
    Content type: Brief Report Published on:

  12. Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a st...

    Authors: Diego Hidalgo-Mazzei, Tim Mantingh, Xavier Pérez de Mendiola, Ludovic Samalin, Juan Undurraga, Sergio Strejilevich, Emanuel Severus, Michael Bauer, Ana González-Pinto, Willem A. Nolen, Allan H. Young and Eduard Vieta
    Citation: International Journal of Bipolar Disorders 2023 11:20
    Content type: Research Published on:

  13. Detecting prodromal symptoms of bipolar disorder (BD) has garnered significant attention in recent research, as early intervention could potentially improve therapeutic efficacy and improve patient outcomes. T...

    Authors: Yijun Shao, Yan Cheng, Srikanth Gottipati and Qing Zeng-Treitler
    Citation: International Journal of Bipolar Disorders 2023 11:19
    Content type: Research Published on:

  14. Several studies have reported on the feasibility of electronic (e-)monitoring using computers or smartphones in patients with mental disorders, including bipolar disorder (BD). While studies on e-monitoring ha...

    Authors: Abigail Ortiz, Yunkyung Park, Christina Gonzalez-Torres, Martin Alda, Daniel M. Blumberger, Rachael Burnett, M. Ishrat Husain, Marcos Sanches and Benoit H. Mulsant
    Citation: International Journal of Bipolar Disorders 2023 11:18
    Content type: Research Published on:

  16. Response to lithium (Li) is highly variable in bipolar disorders (BD). Despite decades of research, no clinical predictor(s) of response to Li prophylaxis have been consistently identified. Recently, we develo...

    Authors: C. Marie-Claire, C. Courtin, F. Bellivier, S. Gard, M. Leboyer, J. Scott and B. Etain
    Citation: International Journal of Bipolar Disorders 2023 11:16
    Content type: Brief Report Published on:

  18. Physical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder. Considering the similar sympto...

    Authors: Beny Lafer, Cicera Claudinea Duarte, Julia Maria D’Andrea Greve, Paulo Roberto dos Santos Silva, Karla Mathias de Almeida, Gabriel Okawa Belizario and Lucas Melo Neves
    Citation: International Journal of Bipolar Disorders 2023 11:14
    Content type: Research Published on:

  19. When assessing the value of an intervention in bipolar disorder, researchers and clinicians often focus on metrics that quantify improvements to core diagnostic symptoms (e.g., mania). Providers often overlook...

    Authors: J. E. Siegel-Ramsay, S. J. Sharp, C. J. Ulack, K. S. Chiang, T. Lanza di Scalea, S. O’Hara, K. Carberry, S. M. Strakowski, J. Suarez, E. Teisberg, S. Wallace and J. R. C. Almeida
    Citation: International Journal of Bipolar Disorders 2023 11:13
    Content type: Research Published on:

  20. Bipolar disorder type-I (BD-I) patients are known to show emotion regulation abnormalities. In a previous fMRI study using an explicit emotion regulation paradigm, we compared responses from 19 BD-I patients a...

    Authors: Fumika Kondo, Jocelyne C. Whitehead, Fernando Corbalán, Serge Beaulieu and Jorge L. Armony
    Citation: International Journal of Bipolar Disorders 2023 11:12
    Content type: Research Published on:

  21. Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels...

    Authors: I. Zorrilla, S. Lopez-Zurbano, S. Alberich, I. Barbero, P. Lopez-Pena, E. García-Corres, J. P. Chart Pascual, J. M. Crespo, C. de Dios, V. Balanzá-Martínez and A. Gonzalez-Pinto
    Citation: International Journal of Bipolar Disorders 2023 11:11
    Content type: Research Published on:

  22. Offspring of parents with bipolar disorder (OBD) are at risk for developing mental disorders, and the literature suggests that parenting stress may represent an important risk factor linking parental psychopat...

    Authors: Tiffany Resendes, Lisa Serravalle, Vanessa Iacono and Mark A. Ellenbogen
    Citation: International Journal of Bipolar Disorders 2023 11:10
    Content type: Research Published on:

  23. Stigma affects different life aspects in people living with bipolar disorder and their families. This study aimed to examining the experience of stigma and evaluating predictors, consequences and strategies to...

    Authors: Maryam Latifian, Kianoush Abdi, Ghoncheh Raheb, Sheikh Mohammed Shariful Islam and Rosa Alikhani
    Citation: International Journal of Bipolar Disorders 2023 11:9
    Content type: Research Published on:

  24. Lithium is one of the most consistently effective treatment for mood disorders. However, patients may show a high level of heterogeneity in treatment response across the lifespan. In particular, the benefits o...

    Authors: Delfina Janiri, Gaia Sampogna, Umberto Albert, Filippo Caraci, Giovanni Martinotti, Gianluca Serafini, Alfonso Tortorella, Alessandro Zuddas, Andrea Fiorillo and Gabriele Sani
    Citation: International Journal of Bipolar Disorders 2023 11:8
    Content type: Review Published on:

  25. Bipolar disorder (BD) is higher in developing countries. Childhood trauma exposure is a common environmental risk factor in Colombia and might be associated with a more severe course of bipolar disorder in Low...

    Authors: Hernán Guillen-Burgos, Sergio Moreno-Lopez, Kaleb Acevedo-Vergara, Manuel Pérez-Florez, Catherine Pachón-Garcia and Juan Francisco Gálvez-Flórez
    Citation: International Journal of Bipolar Disorders 2023 11:7
    Content type: Research Published on:

  26. Evidence-based psychotherapies available to treat patients with bipolar disorders (BD) are limited. Dialectical behavior therapy (DBT) may target several common symptoms of BD. We conducted a systematic review...

    Authors: Brett D. M. Jones, Madeha Umer, Mary E. Kittur, Ofer Finkelstein, Siqi Xue, Mikaela K. Dimick, Abigail Ortiz, Benjamin I. Goldstein, Benoit H. Mulsant and Muhammad I. Husain
    Citation: International Journal of Bipolar Disorders 2023 11:6
    Content type: Review Published on:

  27. Individuals with mental health disorders have a higher risk of sexual problems impacting intimate relations and quality of life. For individuals with bipolar disorder (BD) the mood shifts might to a particular...

    Authors: Helle B. Krogh, Maj Vinberg, Gitte Lee Mortensen, Ditte Skakke, Dorthe Nielsen and Annamaria Giraldi
    Citation: International Journal of Bipolar Disorders 2023 11:5
    Content type: Research Published on:

  28. Lithium is well recognized as the first-line maintenance treatment for bipolar disorder (BD). However, besides therapeutic benefits attributed to lithium therapy, the associated side effects including endocrin...

    Authors: Elise Boivin, Brendan Le Daré, Romain Bellay, Cécile Vigneau, Marion Mercerolle and Astrid Bacle
    Citation: International Journal of Bipolar Disorders 2023 11:4
    Content type: Research Published on:

  29. CACNA1C rs1006737 A allele, identified as a genetic risk variant for bipolar disorder (BD), is associated with anomalous functional connectivity in adults with and without BD. Studies have yet to investigate the ...

    Authors: Xinyue Jiang, Alysha A. Sultan, Mikaela K. Dimick, Clement C. Zai, James L. Kennedy, Bradley J. MacIntosh and Benjamin I. Goldstein
    Citation: International Journal of Bipolar Disorders 2023 11:3
    Content type: Research Published on:

  30. Bipolar Disorders (BDs) are chronic mental health disorders that often result in functional impairment and contribute significantly to the disability-adjusted life years (DALY). BDs are historically under-rese...

    Authors: Dung Ezekiel Jidong, M. Ishrat Husain, Tarela J. Ike, Nusrat Husain, Maigari Yusufu Taru, Nwoga Charles Nnaemeka, Christopher Francis, David B. Jack, Shadrack B. Mwankon, Siqi Xue, Juliet Y. Pwajok, Pam P. Nyam and Maisha Murshed
    Citation: International Journal of Bipolar Disorders 2023 11:2
    Content type: Research Published on:

  31. Given the likelihood of progressive illness in bipolar disorder (BD), it is important to understand the benefits and risks of interventions administered early in illness course. We conducted a systematic revie...

    Authors: A. Ratheesh, D. Hett, J. Ramain, E. Wong, L. Berk, P. Conus, M. A. Fristad, T. Goldstein, M. Hillegers, S. Jauhar, L. V. Kessing, D. J. Miklowitz, G. Murray, J. Scott, M. Tohen, L. N. Yatham…
    Citation: International Journal of Bipolar Disorders 2023 11:1
    Content type: Review Published on:

  32. Lithium is the gold standard prophylactic treatment for bipolar disorder. Most clinical practice guidelines recommend regular calcium assessments as part of monitoring lithium treatment, but easy-to-implement ...

    Authors: Zoltan Kovacs, Peter Vestergaard, Rasmus W. Licht, Sune P. V. Straszek, Anne Sofie Hansen, Allan H. Young, Anne Duffy, Bruno Müller-Oerlinghausen, Florian Seemueller, Gabriele Sani, Janusz Rubakowski, Josef Priller, Lars Vedel Kessing, Leonardo Tondo, Martin Alda, Mirko Manchia…
    Citation: International Journal of Bipolar Disorders 2022 10:34
    Content type: Research Published on:

  35. The occurrence of psychotic features within mood episodes in patients with bipolar I disorder (BD I) has been associated in some studies with a more severe clinical and socio-professional profile. In contrast,...

    Authors: Julien Elowe, Julie Vallat, Enrique Castelao, Marie-Pierre F. Strippoli, Mehdi Gholam, Setareh Ranjbar, Jennifer Glaus, Kathleen Merikangas, Benjamin Lavigne, Pierre Marquet, Martin Preisig and Caroline L. Vandeleur
    Citation: International Journal of Bipolar Disorders 2022 10:31
    Content type: Research Published on:

  37. The COVID-19 pandemic gives us the unique opportunity to study the course of psychiatric symptoms and resilience in older adults with bipolar disorder (OABD) whilst experiencing a collective long lasting stres...

    Authors: Melis Orhan, Nicole Korten, Almar Kok, Dore Loef, Ralph Kupka, Sigfried Schouws, Patricia van Oppen and Annemiek Dols
    Citation: International Journal of Bipolar Disorders 2022 10:29
    Content type: Research Published on:

  38. Overall functioning is already impaired in patients newly diagnosed with bipolar disorder (BD) and, to a lesser degree, also in their unaffected first-degree relatives (UR). Further, aggregation of psychiatric...

    Authors: Kimie Stefanie Ormstrup Sletved, Katrine Maiggaard, Anne Amalie Elgaard Thorup, Lars Vedel Kessing and Maj Vinberg
    Citation: International Journal of Bipolar Disorders 2022 10:28
    Content type: Research Published on:

  40. Physical activity has been proposed to be beneficial for the symptomatic control of bipolar disorder, but the duration of the effects, sex-specific mechanisms, and impact of exercise intensity are not known.

    Authors: Martina Svensson, Sophie Erhardt, Ulf HÃ¥llmarker, Stefan James and Tomas Deierborg
    Citation: International Journal of Bipolar Disorders 2022 10:26
    Content type: Research Published on:

  41. Impulsivity is a prominent feature of bipolar disorder associated with various negative sequelae; moreover, it may be a precursor to shifts in affect or mood, but little is known about its association with aff...

    Authors: Madison K. Titone, Colin Depp, Federica Klaus, Jessica Carrasco, Jared W. Young and Lisa T. Eyler
    Citation: International Journal of Bipolar Disorders 2022 10:25
    Content type: Research Published on:

  42. The efficacy and safety of adjunctive therapy are unclear in bipolar depression. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of second-generation antipsychotic, la...

    Authors: Taku Maruki, Tomohiro Utsumi, Masahiro Takeshima, Yu Fujiwara, Marie Matsui, Yumi Aoki, Hiroyuki Toda, Norio Watanabe, Koichiro Watanabe and Yoshikazu Takaesu
    Citation: International Journal of Bipolar Disorders 2022 10:24
    Content type: Review Published on:

  43. In the 1970 s, scientific research on psychiatric nosology was summarized in Research Diagnostic Criteria (RDC), based solely on empirical data, an important source for the third revision of the official nomen...

    Authors: S. Nassir Ghaemi, Jules Angst, Paul A. Vohringer, Eric A. Youngstrom, James Phelps, Philip B. Mitchell, Roger S. McIntyre, Michael Bauer, Eduard Vieta and Samuel Gershon
    Citation: International Journal of Bipolar Disorders 2022 10:23
    Content type: GUIDELINE Published on:

  44. Preliminary evidence suggests that Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment for bipolar disorder (BD). A proposed working mechanism of MBCT in attenuating depressive symptoms is redu...

    Authors: Jelle Lubbers, Dirk Geurts, Imke Hanssen, Marloes Huijbers, Jan Spijker, Anne Speckens and Mira Cladder-Micus
    Citation: International Journal of Bipolar Disorders 2022 10:22
    Content type: Research Published on:

  46. Lamotrigine is approved as a maintenance therapy for bipolar I disorder in many countries, including China in 2021. This study evaluated the efficacy and safety of lamotrigine in controlling relapse and/or rec...

    Authors: Ling Zhang, Honggeng Zhang, Lu-xian Lv, Qingrong Tan, Xiufeng Xu, Jian Hu, Lu Zi, James Cooper, Abhay Phansalkar and Gang Wang
    Citation: International Journal of Bipolar Disorders 2022 10:20
    Content type: Research Published on:

  47. Bipolar disorder (BD) is one of the leading causes of disability worldwide. However, the prevalence and predictors of long-term work disability among patients with type I and II BD have scarcely been studied. ...

    Authors: Petri Arvilommi, Sanna Pallaskorpi, Outi Linnaranta, Kirsi Suominen, Sami Leppämäki, Hanna Valtonen and Erkki Isometsä
    Citation: International Journal of Bipolar Disorders 2022 10:19
    Content type: Research Published on:

  48. This is a narrative review about the role of classic and two atypical psychedelics in the treatment of unipolar and bipolar depression. Since the 1990s, psychedelics experience a renaissance in biomedical rese...

    Authors: Oliver G. Bosch, Simon Halm and Erich Seifritz
    Citation: International Journal of Bipolar Disorders 2022 10:18
    Content type: Review Published on:

  49. This study sought to examine the association between prospective suicidal behavior and variability, intensity, and persistence of suicidal ideation (SI) in bipolar disorder (BD).

    Authors: Bartholt Bloomfield-Clagett, Dede K. Greenstein, Carlos A. Zarate Jr. and Elizabeth D. Ballard
    Citation: International Journal of Bipolar Disorders 2022 10:17
    Content type: Research Published on:

  50. Some studies suggest a mood-congruent attentional bias in bipolar patients. However, for euthymic patients, especially in dependence on the predominant polarity, there is little and inconsistent data. A cleare...

    Authors: Martina Wenzel, Heike Althen, Julia Veeh and Andreas Reif
    Citation: International Journal of Bipolar Disorders 2022 10:16
    Content type: Research Published on:
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