Articles

25 Years of the International Bipolar Collaborative Network (BCN)

The Stanley Foundation Bipolar Treatment Outcome Network (SFBN) recruited more than 900 outpatients from 1995 to 2002 from 4 sites in the United States (US) and 3 in the Netherlands and Germany (abbreviated as...

Authors: Robert M. Post, Lori L. Altshuler, Ralph Kupka, Susan L. McElroy, Mark A. Frye, Heinz Grunze, Trisha Suppes, Paul E. Keck Jr and Willem A. Nolen

Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia

Impaired working memory is a core cognitive deficit in both bipolar disorder and schizophrenia. Its study might yield crucial insights into the underpinnings of both disorders on the cognitive and neurophysiol...

Authors: Catherine V. Barnes-Scheufler, Caroline Passow, Lara Rösler, Jutta S. Mayer, Viola Oertel, Sarah Kittel-Schneider, Silke Matura, Andreas Reif and Robert A. Bittner

Internet of things issues related to psychiatry

Internet of Things (IoT) devices for remote monitoring, diagnosis, and treatment are widely viewed as an important future direction for medicine, including for bipolar disorder and other mental illness. The nu...

Authors: Scott Monteith, Tasha Glenn, John Geddes, Emanuel Severus, Peter C. Whybrow and Michael Bauer

Overview of lithium's use: a nationwide survey

Lithium is considered the gold standard treatment for bipolar disorder (BD). Current clinical guidelines and scientific evidence support its use as a first-line treatment in BD. However, over the last two deca...

Authors: Xabier Pérez de Mendiola, Diego Hidalgo-Mazzei, Eduard Vieta and Ana González-Pinto

Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus

Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. Interleukin-6 (IL-6), a ...

Authors: Dominik K. E. Beyer, Annika Mattukat and Nadja Freund

Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study

The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) exp...

Authors: Maria Faurholt-Jepsen, Vibe Gedsø Frøkjær, Arafat Nasser, Niklas Rye Jørgensen, Lars Vedel Kessing and Maj Vinberg

Melanopsin-mediated pupillary responses in bipolar disorder—a cross-sectional pupillometric investigation

Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induc...

Authors: Helle Østergaard Madsen, Shakoor Ba-Ali, Steffen Heegaard, Ida Hageman, Ulla Knorr, Henrik Lund-Andersen, Klaus Martiny and Lars Vedel Kessing

Role of endogenous ouabain in the etiology of bipolar disorder

Bipolar disorder is a severe psychiatric illness with poor prognosis and problematic and suboptimal treatments. Understanding the pathoetiologic mechanisms may improve treatment and outcomes.

Authors: Rif S. El-Mallakh, Yonglin Gao and Pan You

Blood pressure in bipolar disorder: evidence of elevated pulse pressure and associations between mean pressure and mood instability

Bipolar disorder (BD) is associated with excess and premature cardiovascular mortality. Elevated blood pressure (BP) is a leading contributor to cardiovascular risk. However, few studies have examined BP in BD...

Authors: Niall M. McGowan, Molly Nichols, Amy C. Bilderbeck, Guy M. Goodwin and Kate E. A. Saunders

Respiratory infections during lithium and valproate medication: a within-individual prospective study of 50,000 patients with bipolar disorder

In vitro studies have demonstrated that lithium has antiviral properties, but evidence from human studies is scarce. Lithium is used as a mood stabilizer to treat patients with bipolar disorder. Here, the aim ...

Authors: Mikael Landén, Henrik Larsson, Paul Lichtenstein, Johan Westin and Jie Song

Has Bipolar Disorder become a predominantly female gender related condition? Analysis of recently published large sample studies

Bipolar Disorders (BD) are disabling and severe psychiatric disorders, commonly perceived as equally affecting both men and women. The prevalence of BD in the general population has been growing over the last ...

Authors: Bernardo Dell’Osso, Rita Cafaro and Terence A. Ketter

A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder

Both bipolar disorder and major depressive disorder are characterized by difficulties in emotion regulation. Little is known about which specific emotion regulatory patterns may be transdiagnostic versus disor...

Authors: Christie W. Musket, Natasha S. Hansen, Keith M. Welker, Kirsten E. Gilbert and June Gruber

Chronic kidney disease in lithium-treated patients, incidence and rate of decline

Lithium-induced nephropathy is a known long-term complication, sometimes limiting the use of lithium as mood stabilizer. The aim of this study is to establish the incidence of chronic kidney disease and the ra...

Authors: Arjan M. Van Alphen, Tessa M. Bosch, Ralph W. Kupka and Rocco Hoekstra

Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium

To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term tr...

Authors: Diane Grillault Laroche, Bruno Etain, Emanuel Severus, Jan Scott and Frank Bellivier

Digital health developments and drawbacks: a review and analysis of top-returned apps for bipolar disorder

Although a growing body of literature highlights the potential benefit of smartphone-based mobile apps to aid in self-management and treatment of bipolar disorder, it is unclear whether such evidence-based app...

Authors: Sarah Lagan, Abinaya Ramakrishnan, Evan Lamont, Aparna Ramakrishnan, Mark Frye and John Torous

Recommendations for the use of long-term experience sampling in bipolar disorder care: a qualitative study of patient and clinician experiences

Self-monitoring has been shown to improve the self-management and treatment of patients with bipolar disorder. However, current self-monitoring methods are limited to once-daily retrospectively assessed mood, ...

Authors: Fionneke M. Bos, Evelien Snippe, Richard Bruggeman, Bennard Doornbos, Marieke Wichers and Lian van der Krieke

An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders

Evidence mapping is a structured approach used to synthesize the state-of-the-art in an emerging field of research when systematic reviews or meta-analyses are deemed inappropriate. We employed this strategy t...

Authors: Jan Scott, Francesc Colom, Allan Young, Frank Bellivier and Bruno Etain

Defining phenotypes of long-term lithium and valproate response, including combination therapy: a modified application of the Alda scale in patients with bipolar disorders

When evaluating the long-term treatment response to mood stabilizers using the Alda scale, mood stabilizer combination therapy is typically considered a confounding factor, and patients receiving combination t...

Authors: Jinyoung Lee, Ji Hyun Baek, Dongbin Lee, Sung Woo Ahn, So-Yung Yang, Yujin Choi, Yong Chun Bahk and Kyung Sue Hong

Misperception of sleep in bipolar disorder: an exploratory study using questionnaire versus actigraphy

The concept of misperception of sleep refers to the estimated discrepancy between subjective and objective measures of sleep. This has been assessed only in a few prior studies in individuals with Bipolar Diso...

Authors: Henrik Myhre Ihler, Manon Meyrel, Vincent Hennion, Julia Maruani, Gregory Gross, Pierre A. Geoffroy, Trine Vik Lagerberg, Ingrid Melle, Frank Bellivier, Jan Scott and Bruno Etain

Digital phenotyping: towards replicable findings with comprehensive assessments and integrative models in bipolar disorders

Digital phenotyping promises to unobtrusively obtaining a continuous and objective input of symptomatology from patients’ daily lives. The prime example are bipolar disorders, as smartphone parameters directly...

Authors: Ulrich W. Ebner-Priemer, Esther Mühlbauer, Andreas B. Neubauer, Holger Hill, Fabrice Beier, Philip S. Santangelo, Philipp Ritter, Nikolaus Kleindienst, Michael Bauer, Florian Schmiedek and Emanuel Severus

The feasibility of mindfulness-based cognitive therapy for people with bipolar disorder: a qualitative study

Mindfulness- Based Cognitive Therapy (MBCT) could be a promising psychosocial intervention for people with bipolar disorder (BD). However, little is known about the feasibility of MBCT for people with BD. In t...

Authors: Imke Hanssen, Nicole van der Horst, Marieke Boele, Marc Lochmann van Bennekom, Eline Regeer and Anne Speckens

Smartphone-based activity measurements in patients with newly diagnosed bipolar disorder, unaffected relatives and control individuals

In DSM-5 activity is a core criterion for diagnosing hypomania and mania. However, there are no guidelines for quantifying changes in activity. The objectives of the study were (1) to investigate daily smartph...

Authors: Sharleny Stanislaus, Maj Vinberg, Sigurd Melbye, Mads Frost, Jonas Busk, Jakob E. Bardram, Lars Vedel Kessing and Maria Faurholt-Jepsen

New vision on the mental problems of Vincent van Gogh; results from a bottom-up approach using (semi-)structured diagnostic interviews

On July 29, 1890 at the age of 37 years, the Dutch painter Vincent van Gogh died from the consequences of a suicide attempt with a gun 2 days earlier. Since then many medical and psychological theories were su...

Authors: Willem A. Nolen, Erwin van Meekeren, Piet Voskuil and Willem van Tilburg

Patient-evaluated cognitive function measured with smartphones and the association with objective cognitive function, perceived stress, quality of life and function capacity in patients with bipolar disorder

Cognitive impairments in patients with bipolar disorder (BD) have been associated with reduced functioning. Aims: To investigate the association between (1) patient-evaluated cognitive function measured daily ...

Authors: Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Mads Frost, Ellen Margrethe Christensen, Helga Þórarinsdóttir, Jakob Eyvind Bardram, Maj Vinberg and Lars Vedel Kessing

Survey of psychiatrist use of digital technology in clinical practice

Psychiatrists were surveyed to obtain an overview of how they currently use technology in clinical practice, with a focus on psychiatrists who treat patients with bipolar disorder.

Authors: Rita Bauer, Tasha Glenn, Scott Monteith, Peter C. Whybrow and Michael Bauer

Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

Many frequently used instruments fail to assess psychosocial functioning in patients with bipolar disorder. The Functioning Assessment Short Test (FAST) was developed in order to tackle this problem and to ass...

Authors: Melis Orhan, Nicole Korten, Ralph Kupka, Patricia van Oppen, Max Stek, Eduard Vieta, Sigfried Schouws, Wouter van Ballegooijen and Annemiek Dols

A multi-center naturalistic study of a newly designed 12-sessions group psychoeducation program for patients with bipolar disorder and their caregivers

Psychoeducation (PE) for bipolar disorder (BD) has a first-line recommendation for the maintenance treatment phase of BD. Formats vary greatly in the number of sessions, whether offered individually or in a gr...

Authors: Susan Zyto, Nienke Jabben, Peter F. J. Schulte, Eline J. Regeer, Peter J. J. Goossens and Ralph W. Kupka

Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months—a developmental pathway to enhanced risk?

Bipolar offspring are considered a high-risk group for developing mental disorders. Developmental outcomes result from additive and interactive effects of biological vulnerability and environmental influences....

Authors: Teija M. S. Anke, Kari Slinning, Vibeke Moe, Cathrine Brunborg, Torill S. Siqveland and Dag Vegard Skjelstad

Low-dose lithium against dementia

Authors: Christopher Baethge

FAB: First UK feasibility trial of a future randomised controlled trial of Family focused treatment for Adolescents with Bipolar disorder

This first mixed-methods UK trial examined the feasibility and acceptability of a future definitive randomised controlled trial (RCT) to evaluate whether Family Focussed Treatment for Adolescents with Bipolar ...

Authors: A. Sharma, M. Glod, T. Forster, R. McGovern, K. McGurk, E. Barron Millar, T. D. Meyer, D. Miklowitz, V. Ryan, L. Vale and A. Le Couteur

Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection

Treatment in bipolar disorder (BD) is commonly applied as a multimodal therapy based on decision algorithms that lack an integrative understanding of molecular mechanisms or a biomarker associated clinical out...

Authors: Alfredo B. Cuéllar-Barboza, Susan L. McElroy, Marin Veldic, Balwinder Singh, Simon Kung, Francisco Romo-Nava, Nicolas A. Nunez, Alejandra Cabello-Arreola, Brandon J. Coombes, Miguel Prieto, Hannah K. Betcher, Katherine M. Moore, Stacey J. Winham, Joanna M. Biernacka and Mark A. Frye

Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife)

Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patie...

Authors: Andrea Pfennig, Karolina Leopold, Julia Martini, Anne Boehme, Martin Lambert, Thomas Stamm, Felix Bermpohl, Andreas Reif, Sarah Kittel-Schneider, Georg Juckel, Andreas J. Fallgatter, Tilo Kircher, Andreas Jansen, Steffi Pfeiffer, Christina Berndt, Maren Rottmann-Wolf…

Treating winter depressive episodes in bipolar disorder: an open trial of light therapy

Light therapy has been used to treat winter depression in bipolar disorder, although the dose, duration, and timing of treatment have differed. The present study is an open trial of light therapy for depressiv...

Authors: Lotte J. E. van Hout, Lisette E. P. Rops and Claudia J. P. Simons

Sleep and physical activity in patients with newly diagnosed bipolar disorder in remission, their first-degree unaffected relatives and healthy controls

Sleep disturbances are a central feature in bipolar disorder (BD) that often persist in remission and seem to be present also in unaffected first-degree relatives (UR) of patients with BD, presenting a possibl...

Authors: Nikolaj Folke la Cour Karottki, Klara Coello, Sharleny Stanislaus, Sigurd Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Lars Vedel Kessing and Maj Vinberg

Lithium’s antiviral effects: a potential drug for CoViD-19 disease?

Since its introduction in modern medicine, naturalistic observations emerged about possible uses of lithium treatment for conditions different from recurring affective disorders, for which it is still a first-...

Authors: Andrea Murru, Mirko Manchia, Tomas Hajek, René E. Nielsen, Janusz K. Rybakowski, Gabriele Sani, Thomas G. Schulze, Leonardo Tondo and Michael Bauer

Diagnostic stability in children and adolescents with bipolar disorder, a nationwide register-based study

Diagnostic stability of bipolar disorder (BD) in children and adolescents, beyond the first contact has been investigated sparsely. The aim of this study was to investigate the diagnostic stability of BD in ch...

Authors: Mathilde Frahm Laursen, Rasmus W. Licht, Christoph U. Correll, Tobias Kallehauge, Ann-Eva Christensen, Maria Rodrigo-Domingo and René Ernst Nielsen

The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective registry

To compare illness characteristics, treatment history, response and durability, and suicidality scores over a 5-year period in patients with treatment-resistant bipolar depression participating in a prospectiv...

Authors: R. Hamish McAllister-Williams, Soraia Sousa, Arun Kumar, Teresa Greco, Mark T. Bunker, Scott T. Aaronson, Charles R. Conway and A. John Rush

Prepubertal bipolar disorder: a diagnostic quandary?

Authors: Gin S. Malhi and Erica Bell

Reflections on: "The diagnosis of bipolar disorder in pre-pubertal children—what was the controversy about and what did we learn as a result?"

It can be argued that the controversy over paediatric bipolar disorder has been useful in highlighting the issue of bipolar disorder in youths generally. Arising out of this controversy is the recognition that...

Authors: Anthony James

Pre-pubertal bipolar disorder: origins and current status of the controversy

Evidence from epidemiological, clinical and high-risk studies has established that the peak period of risk for onset of bipolar disorder spans late adolescence and early adulthood. However, the proposal of the...

Authors: A. Duffy, G. Carlson, B. Dubicka and M. H. J. Hillegers

Cortisol levels in unmedicated patients with unipolar and bipolar major depression using hair and saliva specimens

Differentiating between unipolar and bipolar depression can be clinically challenging, especially at first presentation. Patterns of cortisol secretion could aid diagnostic discrimination in affective disorder...

Authors: Andrés Herane-Vives, Danilo Arnone, Valeria de Angel, Andrew Papadopoulos, Toby Wise, Luis Alameda, Kia-Chong Chua, Allan H. Young and Anthony J. Cleare

Mixed mood states and emotion-related urgency in bipolar spectrum disorders: a call for greater investigation

Authors: Jennie A. Jaggers and June Gruber

Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial

The aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma ...

Authors: Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I-Hui Lee, Kao-Ching Chen, Yen-Kuang Yang, Jau-Shyong Hong and Ru-Band Lu

Role of child maltreatment and gender for bipolar symptoms in young adults

Child maltreatment has been shown to be associated with a wide range of mental disorders, including bipolar disorders. In this 2-year follow-up study, recollections of emotional, physical and sexual abuse were...

Authors: Ida S. Haussleiter, Eva Neumann, Sandra Lorek, Bianca Ueberberg and Georg Juckel

Executive functioning but not IQ or illness severity predicts occupational status in bipolar disorder

Bipolar disorder is associated with significant functional deficits including occupational functioning. Despite the high rates of unemployment and sick leave in the patient population, only a limited number of...

Authors: Julia Drakopoulos, Timea Sparding, Caitlin Clements, Erik Pålsson and Mikael Landén

The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known.

Authors: Ashley L. Comes, Darina Czamara, Kristina Adorjan, Heike Anderson-Schmidt, Till F. M. Andlauer, Monika Budde, Katrin Gade, Maria Hake, Janos L. Kalman, Sergi Papiol, Daniela Reich-Erkelenz, Farah Klöhn-Saghatolislam, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Georg Juckel…

A comprehensive assessment of personality traits and psychosocial functioning in parents with bipolar disorder and their intimate partners

Individuals with bipolar disorder (BD) often possess maladaptive traits and present with various difficulties in psychosocial functioning. However, little is known about the intimate partners of adults with bi...

Authors: Lisa Serravalle, Vanessa Iacono, Sheilagh Hodgins and Mark A. Ellenbogen

An integrative analysis of genome-wide association study and regulatory SNP annotation datasets identified candidate genes for bipolar disorder

Bipolar disorder (BD) is a complex mood disorder. The genetic mechanism of BD remains largely unknown.

Authors: Xin Qi, Yan Wen, Ping Li, Chujun Liang, Bolun Cheng, Mei Ma, Shiqiang Cheng, Lu Zhang, Li Liu, Om Prakash Kafle and Feng Zhang

The existential crisis of bipolar II disorder

The issue of categorical vs. dimensional classification of bipolar disorder continues to generate controversy as it has for generations. Despite the evidence that no psychiatric disorder has discrete boundarie...

Authors: Michael Gitlin and Gin S. Malhi

Diagnosing bipolar disorders: ICD-11 and beyond

Authors: Emanuel Severus and Michael Bauer