Table 4 Weight, glucose, and lipid data (all samples; safety population)
From: Quetiapine monotherapy in bipolar II depression: combined data from four large, randomized studies
Mean change from randomization (SD) a | Quetiapine 300 mg/day (n = 298) | Quetiapine 600 mg/day (n = 307) | Placebo (n = 214) |
|---|---|---|---|
Total cholesterol (mg/dL) | −2.3 (2.1) | 0.8 (2.0) | −3.5 (2.5) |
LDL cholesterol (mg/dL) | −5.3 (1.7) | −0.3 (1.7) | −4.4 (1.9) |
HDL cholesterol (mg/dL) | −0.5 (0.6) | −1.6 (0.6) | −1.0 (0.7) |
Triglycerides (mg/dL) | 21.4 (5.9) | 14.2 (4.9) | 9.0 (7.4) |
Glucose (mg/dL) | 3.3 (1.0) | 2.8 (0.9) | 1.8 (1.1) |
Insulin (pmol/L) | 31.0 (8.4) | 24.2 (6.1) | 12.5 (8.5) |
Mean weight change, kg (SE) | 1.0 (0.19) | 1.1 (0.23) | 0.0 (0.17) |
Weight change ≥7%, n (%) | 17 (6.5) | 24 (9.7) | 4 (2.2) |