Skip to main content

Table 1 Treatment impact on mood and anxiety symptoms based on anxiety disorder comorbidity

From: Bipolar disorder with comorbid anxiety disorders: impact of comorbidity on treatment outcome in cognitive-behavioral therapy and psychoeducation

  No anxiety disorder Comorbid anxiety disorder Time effect Anxiety disorder effect Time × anxiety disorder interaction
  Baseline 18 months Baseline 18 months       
  M(SD) M(SD) M(SD) M(SD) F p F p F p
Depression           
 LIFE-Depression 2.28 (1.43) 1.94 (1.23) 2.84 (1.55) 1.94 (1.35) 20.16 <0.001 2.66 0.11 4.36 0.04
 HAMD-17 5.82 (4.38) 4.18 (4.88) 8.39 (5.27) 5.02 (6.05) 19.96 <0.001 7.49 0.01 2.35 0.13
 HAMD-Depression 4.97 (3.69) 3.30 (3.80) 6.54 (4.29) 3.83 (5.04) 22.54 <0.001 4.34 0.04 1.21 0.27
Mania           
 LIFE-Mania 1.39 (0.87) 1.17 (0.49) 1.41 (1.01) 1.15 (0.46) 8.31 0.004 0.01 0.94 0.06 0.81
 CARSM 1.80 (2.61) 1.32 (3.16) 2.35 (3.71) 1.19 (3.19) 5.18 0.024 0.32 0.58 0.91 0.34
Anxiety           
 LIFE-Panic 1.01 (0.08) 1.02 (0.12) 1.25 (0.55) 1.09 (0.40) 3.35 0.07 16.40 <0.001 4.08 0.047
 HAMD-Anxiety 1.02 (1.40) 0.93 (1.45) 2.14 (1.80) 1.26 (1.70) 8.01 0.005 14.75 <0.001 5.41 0.021
  1. Significant effects are italicized. CARSM Clinician-Administered Rating Scale for Mania, HAMD-17 Hamilton Rating Scale for Depression, 17-item version, HAMD-Anxiety, Hamilton Rating Scale for Depression, four anxiety items only, HAMD-Depression Hamilton Rating Scale for Depression, excluding anxiety items, LIFE Longitudinal Interval Follow-up Examination.