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Table 1 Treatment impact on mood and anxiety symptoms based on anxiety disorder comorbidity

From: Bipolar disorder with comorbid anxiety disorders: impact of comorbidity on treatment outcome in cognitive-behavioral therapy and psychoeducation

 

No anxiety disorder

Comorbid anxiety disorder

Time effect

Anxiety disorder effect

Time × anxiety disorder interaction

 

Baseline

18 months

Baseline

18 months

      
 

M(SD)

M(SD)

M(SD)

M(SD)

F

p

F

p

F

p

Depression

          

 LIFE-Depression

2.28 (1.43)

1.94 (1.23)

2.84 (1.55)

1.94 (1.35)

20.16

<0.001

2.66

0.11

4.36

0.04

 HAMD-17

5.82 (4.38)

4.18 (4.88)

8.39 (5.27)

5.02 (6.05)

19.96

<0.001

7.49

0.01

2.35

0.13

 HAMD-Depression

4.97 (3.69)

3.30 (3.80)

6.54 (4.29)

3.83 (5.04)

22.54

<0.001

4.34

0.04

1.21

0.27

Mania

          

 LIFE-Mania

1.39 (0.87)

1.17 (0.49)

1.41 (1.01)

1.15 (0.46)

8.31

0.004

0.01

0.94

0.06

0.81

 CARSM

1.80 (2.61)

1.32 (3.16)

2.35 (3.71)

1.19 (3.19)

5.18

0.024

0.32

0.58

0.91

0.34

Anxiety

          

 LIFE-Panic

1.01 (0.08)

1.02 (0.12)

1.25 (0.55)

1.09 (0.40)

3.35

0.07

16.40

<0.001

4.08

0.047

 HAMD-Anxiety

1.02 (1.40)

0.93 (1.45)

2.14 (1.80)

1.26 (1.70)

8.01

0.005

14.75

<0.001

5.41

0.021

  1. Significant effects are italicized. CARSM Clinician-Administered Rating Scale for Mania, HAMD-17 Hamilton Rating Scale for Depression, 17-item version, HAMD-Anxiety, Hamilton Rating Scale for Depression, four anxiety items only, HAMD-Depression Hamilton Rating Scale for Depression, excluding anxiety items, LIFE Longitudinal Interval Follow-up Examination.