| |
No anxiety disorder
|
Comorbid anxiety disorder
|
Time effect
|
Anxiety disorder effect
|
Time × anxiety disorder interaction
|
|---|
| |
Baseline
|
18 months
|
Baseline
|
18 months
| | | | | | |
|---|
| |
M(SD)
|
M(SD)
|
M(SD)
|
M(SD)
|
F
|
p
|
F
|
p
|
F
|
p
|
|---|
|
Depression
| | | | | | | | | | |
|
LIFE-Depression
|
2.28 (1.43)
|
1.94 (1.23)
|
2.84 (1.55)
|
1.94 (1.35)
|
20.16
|
<0.001
|
2.66
|
0.11
|
4.36
|
0.04
|
|
HAMD-17
|
5.82 (4.38)
|
4.18 (4.88)
|
8.39 (5.27)
|
5.02 (6.05)
|
19.96
|
<0.001
|
7.49
|
0.01
|
2.35
|
0.13
|
|
HAMD-Depression
|
4.97 (3.69)
|
3.30 (3.80)
|
6.54 (4.29)
|
3.83 (5.04)
|
22.54
|
<0.001
|
4.34
|
0.04
|
1.21
|
0.27
|
|
Mania
| | | | | | | | | | |
|
LIFE-Mania
|
1.39 (0.87)
|
1.17 (0.49)
|
1.41 (1.01)
|
1.15 (0.46)
|
8.31
|
0.004
|
0.01
|
0.94
|
0.06
|
0.81
|
|
CARSM
|
1.80 (2.61)
|
1.32 (3.16)
|
2.35 (3.71)
|
1.19 (3.19)
|
5.18
|
0.024
|
0.32
|
0.58
|
0.91
|
0.34
|
|
Anxiety
| | | | | | | | | | |
|
LIFE-Panic
|
1.01 (0.08)
|
1.02 (0.12)
|
1.25 (0.55)
|
1.09 (0.40)
|
3.35
|
0.07
|
16.40
|
<0.001
|
4.08
|
0.047
|
|
HAMD-Anxiety
|
1.02 (1.40)
|
0.93 (1.45)
|
2.14 (1.80)
|
1.26 (1.70)
|
8.01
|
0.005
|
14.75
|
<0.001
|
5.41
|
0.021
|
- Significant effects are italicized. CARSM Clinician-Administered Rating Scale for Mania, HAMD-17 Hamilton Rating Scale for Depression, 17-item version, HAMD-Anxiety, Hamilton Rating Scale for Depression, four anxiety items only, HAMD-Depression Hamilton Rating Scale for Depression, excluding anxiety items, LIFE Longitudinal Interval Follow-up Examination.
