Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events

Saunders, Erika FH; Novick, Danielle M; Fernandez-Mendoza, Julio; Kamali, Masoud; Ryan, Kelly A; Langenecker, Scott A; Gelenberg, Alan J; McInnis, Melvin G

doi:10.1186/2194-7511-1-16

International Journal of Bipolar Disorders

Table 4 Correlates of poor sleep quality in euthymic bipolar subjects ( n = 119)

From: Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events

Domain	Bivariate	Multivariable regression models ^a	Unified multivariable regression model ^b
Domain	r	β( p)	β( p)
Sociodemographic		Adjusted R² = .09	Adjusted R² = .20
Married	−.23 (.01)	−.21 (.02)	-
Age	4 × 10⁻³	-	-
Menopausal status (F)	.01	-	-
Sex	.04	-	-
Employed	−.13	-	-
Medical and anxiety disorder comorbidities		Adjusted R² = .11
Cardiovascular disease	.20 (.03)	.16 (.08)	-
BMI	.17 (.07)	-	-
Diabetes	.05	-	-
Migraine	.13	-	-
Alcohol use disorders	.16 (.08)	-	-
Drug use disorders	.17 (.07)	.17 (.07)	-
Anxiety disorder	−.09	-	-
Features of BD		Adjusted R² = .15
Suicide attempts	.31 (1 × 10⁻³)	.22 (.02)	-
Rapid cycling	.30 (1 × 10⁻³)	.20 (.04)	.20 (.03)
Mixed episodes	.20 (.04)	-	-
Mixed symptoms	.13	-	-
Psychosis	.11	-	-
Severity/symptom measures		Adjusted R² = .06
Age at onset	−.20 (.03)	−.18 (.07)	-
Depression (number of episodes)	.33 (<1 × 10⁻³)	-	-
Mania (number of episodes)	.16 (.09)	-	-
Hypomania (number of episodes)	.23 (.01)	-	-
Current symptom state
HDRS 17	.11	-	-
HDRS 21 with atypical symptoms	.24 (.01)	-	-
YMRS	−.01	-	-
Chronotype and sleepiness		Adjusted R² = .10
MCTQ chronotype	.24 (.01)	.23 (.01)	-
ESS sleepiness	.16 (.08)	-	-
Personality assessment		Adjusted R² = .13
NEO-PI neuroticism	.35 (<1 × 10⁻³)	.31 (1 × 10⁻³)	.28 (2 × 10⁻³)
NEO-PI extraversion	−.01	-	-
NEO-PI openness	.06	-	-
NEO-PI agreeableness	−.01	-	-
NEO-PI conscientiousness	−.17 (.08)	-	-
Life story		Adjusted R² = .11
LEOS undesirable events	.26 (.01)	.27 (.01)	.20 (.02)
CTQ childhood trauma	.19 (.04)	-	-
LEC stressful life events	.09	-	-
FACES-II cohesion	−.20 (.03)	-	-
FACES-II adaptability	−.15	-	-
MRCIR social support	−.20 (.03)	-	-
MRCIR undermining	.10	-	-
Behavioral
AUDIT alcohol	−.07	-	-
AUDIT drugs	−.10	-	-
FTND nicotine dependence	.13	-	-

^aSet of predictors in a series of linear regressions with backward selection in each domain after adjusting for depressive symptoms (β ranges from .17 to .26, p < .07); ^bmultivariable linear regression, final model obtained through backward selection.

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