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Table 1 Mean methylation fractions for BDNF CpG units in bipolar disorder versus controls

From: Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder

Amplicon CpG unit BP MMF (SD) Controls MMF (SD) Z Asymp. sig. Cohen's d
D2a 1, 2 0.354 (0.077) 0.335 (0.067) −1.712 0.087  
11, 26 0.156 (0.025) 0.159 (0.038) −0.061 0.951  
12, 13, 14 0.301 (0.030) 0.289 (0.034) −1.864 0.062  
15 0.103 (0.022) 0.100 (0.026) −0.682 0.495  
16 0.086 (0.012) 0.082 (0.015) 1.797 0.072  
17 0.122 (0.032) 0.116 (0.015) −2.33 0.02*  
18, 19, 20 0.242 (0.032) 0.232 (0.035) −1.789 0.072  
21 0.128 (0.014) 0.126 (0.023) −0.449 0.654  
22, 23 0.275 (0.018) 0.260 (0.023) −2.094 0.036*  
24 0.089 (0.011) 0.086 (0.028) −1.217 0.224  
27, 28, 29, 30 0.246 (0.031) 0.238 (0.014) −1.284 0.199  
3 0.355 (0.034) 0.333 (0.032) −3.315 0.001 ** 0.680
4 0.054 (0.025) 0.048 (0.031) −1.054 0.292  
5, 6 0.279 (0.047) 0.274 (0.022) −0.733 0.464  
9, 10 0.254 (0.034) 0.255 (0.038) −0.256 0.798  
D3 11, 12, 13 0.227 (0.014) 0.217 (0.019) −2.889 0.004 ** 0.610
14 0.085 (0.011) 0.079 (0.017) −2.37 0.018*  
15, 16, 17 0.181 (0.016) 0.163 (0.027) −2.993 0.003 ** 0.840
18 0.068 (0.012) 0.061 (0.011) −3.179 0.001 ** 0.610
19 0.055 (0.011) 0.056 (0.012) −0.157 0.875  
2, 3, 4 0.284 (0.019) 0.282 (0.020) −0.484 0.628  
20 0.480 (0.068) 0.504 (0.101) −0.728 0.466  
21 0.021 (0.008) 0.021 (0.015) −0.728 0.466  
22, 23, 8 0.136 (0.008) 0.126 (0.014) −3.8 <0.001 ** 0.910
5, 6 0.316 (0.029) 0.302 (0.054) −0.601 0.548  
7 0.068 (0.011) 0.066 ()0.016 −0.799 0.424  
9, 10 0.069 (0.009) 0.066 (0.012) −2.017 0.044*  
D5 11, 12, 13 0.233 (0.030) 0.220 −1.962 0.05*  
14 0.065 (0.014) 0.063 −0.853 0.394  
15 0.253 (0.085) 0.253 −0.155 0.877  
16 0.093 (0.022) 0.083 −2.119 0.034*  
17, 18, 19 0.172 (0.017) 0.160 −2.447 0.014*  
4, 5 0.168 (0.097) 0.200 −1.09 0.276  
6 0.056 (0.017) 0.057 −0.391 0.696  
7, 8 0.205 (0.021) 0.197 1.671 0.095  
9 0.061 (0.048) 0.074 −1.35 0.177  
  1. *Significant at alpha = 0.05; ** significant after FDR, alpha = 0.004; BP, bipolar disorder. MMF, mean methylation; d, effect size; Z, Mann Whitney U test statistic.