Table 1 Mean methylation fractions for BDNF CpG units in bipolar disorder versus controls

1, 2

0.354 (0.077)

0.335 (0.067)

−1.712

0.087

11, 26

0.156 (0.025)

0.159 (0.038)

−0.061

0.951

12, 13, 14

0.301 (0.030)

0.289 (0.034)

−1.864

0.062

15

0.103 (0.022)

0.100 (0.026)

−0.682

0.495

16

0.086 (0.012)

0.082 (0.015)

1.797

0.072

17

0.122 (0.032)

0.116 (0.015)

−2.33

0.02*

18, 19, 20

0.242 (0.032)

0.232 (0.035)

−1.789

0.072

21

0.128 (0.014)

0.126 (0.023)

−0.449

0.654

22, 23

0.275 (0.018)

0.260 (0.023)

−2.094

0.036*

24

0.089 (0.011)

0.086 (0.028)

−1.217

0.224

27, 28, 29, 30

0.246 (0.031)

0.238 (0.014)

−1.284

0.199

3

0.355 (0.034)

0.333 (0.032)

−3.315

0.001 **

0.680

4

0.054 (0.025)

0.048 (0.031)

−1.054

0.292

5, 6

0.279 (0.047)

0.274 (0.022)

−0.733

0.464

9, 10

0.254 (0.034)

0.255 (0.038)

−0.256

0.798

11, 12, 13

0.227 (0.014)

0.217 (0.019)

−2.889

0.004 **

0.610

14

0.085 (0.011)

0.079 (0.017)

−2.37

0.018*

15, 16, 17

0.181 (0.016)

0.163 (0.027)

−2.993

0.003 **

0.840

18

0.068 (0.012)

0.061 (0.011)

−3.179

0.001 **

0.610

19

0.055 (0.011)

0.056 (0.012)

−0.157

0.875

2, 3, 4

0.284 (0.019)

0.282 (0.020)

−0.484

0.628

20

0.480 (0.068)

0.504 (0.101)

−0.728

0.466

21

0.021 (0.008)

0.021 (0.015)

−0.728

0.466

22, 23, 8

0.136 (0.008)

0.126 (0.014)

−3.8

<0.001 **

0.910

5, 6

0.316 (0.029)

0.302 (0.054)

−0.601

0.548

7

0.068 (0.011)

0.066 ()0.016

−0.799

0.424

9, 10

0.069 (0.009)

0.066 (0.012)

−2.017

0.044*

11, 12, 13

0.233 (0.030)

0.220

−1.962

0.05*

14

0.065 (0.014)

0.063

−0.853

0.394

15

0.253 (0.085)

0.253

−0.155

0.877

16

0.093 (0.022)

0.083

−2.119

0.034*

17, 18, 19

0.172 (0.017)

0.160

−2.447

0.014*

4, 5

0.168 (0.097)

0.200

−1.09

0.276

6

0.056 (0.017)

0.057

−0.391

0.696

7, 8

0.205 (0.021)

0.197

1.671

0.095

9

0.061 (0.048)

0.074

−1.35

0.177