Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder

International Journal of Bipolar Disorders

Table 2 Interaction between genotype and high-risk status and genotype and clinical stage

	Genotype × high-risk status predicting log mRNA expression	Genotype × high-risk status predicting protein levels	Genotype × clinical stage predicting log mRNA expression	Genotype × clinical stage predicting protein levels
	p value	p value	p value	p value
BDNF	0.0276	0.0403	0.0634	0.4785
TNF	0.1701	0.6675	0.1438	0.5853
IFN	0.3378	0.9346	0.7294	0.9805
IL-6	0.4774	0.1593	0.7182	0.0688
IL-10	0.5449	0.3154	0.2591	0.3105

log mRNA expression presented as log fold-change; protein levels are measured in picograms per microgram. All values are adjusted for sex, age, SES, and GAF.