|
Demographics
| | | |
|
Age, years, mean (SD)
|
43.0 (12.8)
|
43.8 (12.9)
|
0.44
|
|
Weight, kg, mean (SD)
|
73.5 (13.8)
|
73.9 (14.1)
|
0.69
|
|
Height, cm, mean (SD)
|
168.1 (9.3)
|
167.1 (8.8)
|
0.11
|
|
Sex, females, n (%)
|
337 (56.7)
|
176 (59.3)
|
0.47
|
|
Race, n (%)
| | |
0.30
|
|
Caucasian
|
384 (65.1)
|
198 (67.3)
| |
|
Hispanic
|
37 (6.3)
|
24 (8.2)
| |
|
East Asian
|
169 (28.6)
|
72 (24.5)
| |
|
Clinical characteristics
| | | |
|
CGI-S, mean (SD)
|
2.4 (0.7)
|
2.6 (0.7)
|
0.002
|
|
DAI-10, mean (SD)
|
5.7 (3.7)
|
4.8 (4.0)
|
0.002
|
|
Days bipolar inpatient last year, mean (SD)
|
15.4 (38.5)
|
18.4 (32.8)
|
0.029
|
|
Recent relapse, n (%)
|
68 (11.4)
|
68 (22.9)
|
<0.001
|
|
Functional characteristics
| | | |
|
EQ-5D overall health status score (SD)
|
0.9 (0.2)
|
0.8 (0.2)
|
0.0012
|
|
EQ-5D VAS score (SD)
|
74.2 (15.4)
|
69.6 (17.6)
|
<0.001
|
|
Number of activities with friends or social groups, n (%)
| | | |
|
0
|
100 (16.8)
|
85 (29.0)
| |
|
1
|
66 (11.1)
|
40 (13.7)
|
<0.001
|
|
2
|
117 (19.7)
|
49 (16.7)
| |
|
3
|
78 (13.1)
|
40 (13.7)
| |
|
4
|
70 (11.8)
|
20 (6.8)
| |
|
≥5
|
163 (27.4)
|
59 (20.1)
| |
|
Work activity, n (%)
| | | |
|
Unable to work
|
34 (5.8)
|
26 (9.0)
|
<0.001
|
|
Volunteer work
|
21 (3.6)
|
6 (2.1)
| |
|
Student
|
34 (5.8)
|
12 (4.1)
| |
|
Working for pay
|
199 (33.8)
|
76 (26.2)
| |
|
Keeping house
|
109 (18.5)
|
48 (16.6)
| |
|
Unemployed
|
59 (10.0)
|
23 (7.9)
| |
|
Sheltered program
|
15 (2.5)
|
3 (1.0)
| |
|
Retired
|
118 (20.0)
|
96 (33.1)
| |
|
Impairment in work activities, n (%)
| | | |
|
No impairment
|
123 (20.8)
|
39 (13.3)
| |
|
Mild impairment
|
220 (37.2)
|
81 (27.6)
| |
|
Moderate impairment
|
150 (25.4)
|
133 (45.2)
| |
|
Severe impairment
|
50 (8.5)
|
22 (7.5)
| |
|
Unable to work due to mental illness
|
31 (5.2)
|
15 (5.1)
|
<0.001
|
|
Patient-physician relationship, n (%)
| | | |
|
Poor
|
0
|
7 (2.4)
|
<0.001
|
|
Fair
|
20 (3.4)
|
25 (8.4)
| |
|
Good
|
158 (26.6)
|
148 (49.8)
| |
|
Very good
|
277 (46.6)
|
101 (34.0)
| |
|
Excellent
|
139 (23.4)
|
16 (5.4)
| |
|
Insight into illness, n (%)
| | | |
|
None
|
3 (0.5)
|
3 (1.0)
| |
|
Low
|
26 (4.4)
|
49 (16.5)
|
<0.001
|
|
Medium
|
87 (14.6)
|
111 (37.4)
| |
|
Moderate
|
168 (28.3)
|
93 (31.3)
| |
|
High
|
310 (52.2)
|
41 (13.8)
| |
|
Length of previous treatment regimen (4 weeks before baseline, containing olanzapine), n (%)
| | | |
|
<14 days
|
8 (1.3)
|
10 (3.5)
| |
|
15 to 30 days
|
125 (21.1)
|
91 (31.5)
|
<0.001
|
|
31 to 90 days
|
212 (35.8)
|
77 (26.6)
| |
|
>90 days
|
244 (41.1)
|
101 (34.9)
| |
