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Table 1 Quality of evidence (parenthesis) and neuropsychiatric conditions in which BAEs were described (brackets)

From: Behavioral and emotional adverse events of drugs frequently used in the treatment of bipolar disorders: clinical and theoretical implications

 

SSRIs

Lithium

AP

LMT

Apathy—emotional blunting

Arnone et al. (2009) (E) [HV]

Barnhart et al. (2004) (C) [MDD; AD]

Bolling and Kohlenberg (2004) (D) [MDD]

Di Giannantonio and Martinotti (2012) (D) [MDD]

Fava et al. (2006) (D) [MDD]

Garland and Baerg (2001) (F) [MDD; AD]

George and Trimble (1992) (F) [AD]

Harmer et al. ( 2003, 2004, 2008, 2011) (E) [HV]

Harmer et al. (2009) (D) [MDD]

Hoehn-Saric et al. (1990, 1991) ( F) [AD]

McCabe et al. (2010) (E) [HV]

Opbroek et al. (2002) (D) [MDD]

Padala et al. (2012) (F) [MDD; AD]

Popovic et al. (2015) (D) [MDD; AD]

Price et al. (2009) (D) [MDD; AD]

Raskin et al. (2012) (B) [MDD]

Rawlings et al. (2010) (E) [HV]

Reinblatt and Riddle (2006) (D) [AD]

Rothschild et al. (2014) (D) [MDD]

Wongpakaran et al. (2007) (D) [MDD]

Belmaker et al. (1979) (D) [BD]

Bonetti et al. (1977) (D) [BD; MDD]

Folstein et al. (1982) (D) [BD]

Judd et al. (1977) (E) [HV]

Kropf and Muller-Oerlinghausen (Kropf and Müller-Oerlinghausen 1975; Kropf and Muller-Oerlinghausen 1979 ) (E) [HV]

White et al. (1979) (E) [HV]

Awad and Voruganti (2004) ( D) [SZ]

Awad et al. (1996) (D) [SZ]

Belmaker and Wald (1977) (E) [HV]

deHaan et al. (de Haan et al. 2000; De Haan et al. 2005) (D) [SZ]

deHaan et al. (2003) (B) [SZ]

Fischel et al. (2013) (D) [SZ]

Gervin et al. (1999) (D) [SZ]

Kim and Byun (2010) (D) [SZ]

Lambert et al. (2003) (D) [SZ]

Lataster et al. (2011) (D) [SZ]

Lewander (1994) (D) [SZ]

Moncrieff et al. (2009) (D) [SZ; BD]

Takeuchi et al. (2013) (D) [SZ]

N/A

Decision-making impairment

Cools et al. (2008) (E) [HV]

Crockett et al. (2012) (E) [HV]

Macoveanu et al. (2014) (E) [HV]

Molero et al. (2015) (D) [MDD; BD; AD; SZ]

Price et al. (2009) (D) [MDD]

Rogers et al. (1999) (E) [HV]

Rogers et al. (2003) (E) [HV]

Tanaka et al. (2009) (E) [HV]

N/A

Adida et al. (2011) (D) [SZ]

Heerey et al. (2008) (D) [SZ]

Hutton et al. (2002) (D) [SZ]

Poletti et al. (2011) (D) [PD]

Prentice et al. (2005) (D) [SZ]

Sevy et al. (2006) (E) [HV]

Trémeau et al. (2008) (D) [SZ]

Vrshek-Schallhorn et al. (2013) (E) [HV]

N/A

Diminished libido

Atmaca et al. (2011) (D) [MDD]

Aursnes and Gjertsen (2008) (A) [MDD]

Clayton and Montejo (2006) (D) [MDD]

Clayton et al. (2002) (D) [MDD]

Dueñas et al. (2011) (D) [MDD]

Gittlin et al. (2002) (D) [MDD]

Kennedy et al. (2008) (B) [MDD]

Montejo et al. (2001) (D) [MDD]

Opbroek et al. (2002) (D) [MDD]

Serretti and Chiesa (2009) (D) [MDD]

N/A

N/A

N/A

Obsessive–compulsive symptoms

N/A

N/A

DeVylder et al. (2012) (D) [SZ]

Hagen et al. (2013) (D) [SZ]

Jonkers and deHaan (2002) (F) [BD]

Kapur et al. (1998, 1999, 2006) (D) [SZ]

Lemke and Bustillo (2013) (F) [BD]

Lin et al. (2006) (D) [SZ]

Mahendran et al. (2007) (D) [SZ]

Niendam et al. (2009) (D) [SZ]

Schirmbeck and Zink (2012, 2013) (D) [SZ]

Schirmbeck et al. (2011 2013) (D) [SZ]

Stamouli and Lykouras (2006) (F) [MDD; BD; SZ]

Szmulewicz et al. (2015a, b) (D) [SZ]

Alkin et al. (2007) (F) [BD]

Kemp et al. (2007) (F) [BD]

Kuloglu et al. (2009) (F) [BD]

Lee et al. (2011) (D) [E]

Lombroso (1999) (F) [TS]

Seemüller et al. (2006) (F) [BD]

Szmulewicz et al. (2015b) (D) [SZ]

Verma et al. (1999) (F) [E]

Inability to cry

Oleshansky and Labbate (1996) (F) [MDD; AD]

Opbroek et al. (2002) (D) [MDD]

Holguin-Lew and Bell (2013) (F) [MDD; AD]

N/A

N/A

N/A

Self-injuries

Price et al. (2009) (D) [MDD]

Miller et al. (2014) (D) [MDD]

N/A

N/A

N/A

Hypersexuality

N/A

N/A

N/A

Grabowska-Grzyb et al. (2006) (F) [E]

  1. MDD major depressive disorder, AD anxiety disorders, BD bipolar disorder, SZ schizophrenia, PD Parkinson’s disease, E epilepsy, TS Tourette’s Syndrome, HV healthy volunteer
  2. Quality of evidence
  3. A Meta-analysis of randomized controlled trials
  4. B At least one randomized, controlled, double-blinded study
  5. C Systematic review of studies
  6. D Cohort studies/open or non-randomized studies/observational studies in patient sample/Narrative review
  7. E Healthy volunteers studies
  8. F Case report/Case series/Case control studies
  9. N/A Not available