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Table 4 SNP x Toxoplasma gondii interaction

From: Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study

Polymorphism

 

TG positive

TG negative

p value (GxE)

OR TG (+) (CI 95 %)

OR TG (−) (CI 95 %)

MAF BD

MAF HC

MAF BD

MAF HC

TLR2 rs4696480

T/A

0.47

0.53

0.44

0.49

0.923

0.760 (0.51–1.14)

0.805 (0.44–1.47)

TLR2 rs3804099

T/C

0.42

0.45

0.59

0.43

0.021

0.894 (0.62–1.30)

2.289 (1.15–4.58)

TLR4 rs1927914

A/G

0.40

0.37

0.46

0.42

0.992

1.102 (0.76–1.60)

1.154 (0.65–2.05)

TLR4 rs11536891

T/C

0.17

0.11

0.17

0.18

0.341

1.546 (0.91–2.64)

0.944 (0.42–2.14)

NOD2 rs2066842

C/T

0.25

0.28

0.24

0.20

0.408

0.875 (0.56–1.37)

1.300 (0.64–2.63)

  1. SNP single-nucleotide polymorphism; TG Toxoplasma gondii; MAF minor allele frequency; BD bipolar disorder; HC healthy controls; GxE gene–environment interaction; OR odds ratio; CI confidence interval