Repeated salivary daytime cortisol and onset of mood episodes in offspring of bipolar parents

International Journal of Bipolar Disorders

Table 3 The influence of DSM-IV substance use disorders and lifetime psychotic symptoms on the stability of cortisol (nmol/L) in high-risk offspring over repeated annual sampling assessments

Predictor	Main effect	Sampling year interaction^b p value^c	Main effect without interaction^b p value^c	Number of longitudinal observations
CAR	SUD	0.1733	0.1148	101
CAR	Psychotic	0.1687	0.1198	101
logTime 3^d	SUD	0.1633	0.8117	102
logTime 3^d	Psychotic	0.2728	0.0191^a	102
logAUC^e	SUD	0.0346^a	0.1831	95
logAUC^e	Psychotic	<0.0001	0.4902	95

Italic denotes significance after correction for multiple comparisons
SUD substance use disorders, CAR cortisol awakening response, AUC area under the curve (ground), Psychotic lifetime psychotic symptoms in or outside mood episodes
^a p value not significant after Šidák correction for multiple comparisons (p value cutoff of 0.0034)
^bInteraction term was composed of sampling assessment year and presence of lifetime SUD or psychotic symptoms
^cMixed model accounting for sibling correlation adjusted for sex and age at baseline cortisol sample
^d8:00 p.m. cortisol
^eSeconds*nmol/L