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Table 1 Demographics, illness characteristics, current mood symptoms, and current medications in bipolar II disorder versus bipolar I disorder outpatients

From: American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence

 

Recovered bipolar II

Recovered bipolar I

Depressed bipolar II

Depressed bipolar I

N (%)

39.0* (41)

61.0 (64)

61.4** (94)

38.6 (59)

Demographics

A. Age (years, mean ± SD)

36.5 ± 13.8

35.8 ± 13.7

36.5 ± 13.5

35.9 ± 13.5

B. Female (%)

69.0

48.4

63.8

57.6

C. Caucasian (%)

75.0

77.4

87.2

86.4

D. College degree (%)

66.7

60.3

51.1

40.7

E. Married (current, %)

34.1

38.1

41.5

30.5

F. Full-time employment (current, %)

35.0

33.3

25.8

25.4

Comorbid disorders (lifetime, %)

1. Anxiety

61.0*

37.5

81.9

69.5

2. Alcohol/substance use

51.2

50.0

58.5

57.6

3. Eating

14.6

6.3

18.1

6.8

4. Personality

7.3

9.4

19.1*

6.8

Other illness characteristics

5. Bipolar II disorder (%)

100.0****

0.0

100.0****

0.0

5A. Psychosis (lifetime, %)

12.2

68.8****

18.1

64.4****

5B. Psychiatric Hospitalization (lifetime, %)

9.8

70.3****

6.4

57.6****

6. ≥One 1° relative with mood disorder (%)

53.7

42.2

61.7

55.9

7. Onset age (years, mean ± SD)

18.4 ± 9.0

20.1 ± 8.8

16.2 ± 8.7

18.5 ± 5.8

8. Childhood (age <13 years) Onset (%)

20.0

9.4

31.9***

8.5

9. Illness duration (years, mean ± SD)

18.9 ± 15.4

16.4 ± 12.6

19.6 ± 13.5

17.3 ± 12.5

10. Long illness duration (≥15 years, %)

50.0

46.6

54.8

50.8

11. Episode accumulation (≥10, lifetime, %)

63.9

42.9

81.6**

56.4

12. Suicide attempt (lifetime, %)

30.8

23.8

31.2

39.0

13. Rapid cycling (prior year, %)

15.4

6.7

34.4

20.7

14. CGI-BP-OS (current, mean ± SD)

2.4 ± 0.7**

2.0 ± 0.8

5.4 ± 0.8

5.93 ± 0.7

Current mood symptoms (any in prior 10 days, %)

15. Sadness

31.7*

10.9

91.5

86.4

16. Anhedonia

22.4*

7.8

95.7

93.2

17. Euphoria

17.1

10.9

35.1*

16.9

18. Irritability

53.7**

25.0

77.7**

54.2

19. Anxiety

46.3

29.7

85.1

74.6

Medication (current)

20. Mood stabilizer (MS, %)

75.6

77.8

51.1**

75.9

21. Antipsychotic (AP, %)

31.7

40.6

20.2****

55.9

22. Antidepressant (AD, %)

46.3*

25.0

48.9

37.3

23. Anxiolytic/hypnotic (AN, %)

24.4

23.4

31.9

40.7

24. Complex pharmacotherapy (>4 MS, AP, or AD, %)

24.4

15.6

24.5

35.6

25. Number of psychotropics (MS, AP, AD, mean ± SD)

2.6 ± 1.6

2.3 ± 1.3

2.2 ± 1.8*

2.8 ± 1.7

  1. Underline indicates parameters with statistically significant relationships with bipolar subtype; CGI-BP-OS indicates clinical global impression for bipolar disorder-overall severity; italic font indicates parameters associated with bipolar I disorder, independent of mood state; SD indicates standard deviation
  2. Missing data: recovered—≥10 prior episodes 12.4%, all other parameters 0.0–5.7%, depressed—≥10 prior episodes 7.2%, all other parameters 0.0–1.3%
  3. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001, bipolar II disorder versus bipolar I disorder