Poor quality of life and functioning in bipolar disorder

Sylvia, Louisa G.; Montana, Rebecca E.; Deckersbach, Thilo; Thase, Michael E.; Tohen, Maurcio; Reilly-Harrington, Noreen; McInnis, Melvin G.; Kocsis, James H.; Bowden, Charles; Calabrese, Joseph; Gao, Keming; Ketter, Terence; Shelton, Richard C.; McElroy, Susan L.; Friedman, Edward S.; Rabideau, Dustin J.; Nierenberg, Andrew A.

doi:10.1186/s40345-017-0078-4

International Journal of Bipolar Disorders

Table 1 Baseline correlations of quality of life and functioning with demographics, clinical severity, social disadvantage, and current psychiatric comorbidities

From: Poor quality of life and functioning in bipolar disorder

Variable	% (n) or mean + SD	Q-LES-Q		LIFE-RIFT
Variable	% (n) or mean + SD	Coefficient	p value	Coefficient	p value
Demographics
Age	38.9 + 12.1	0.03	0.65	0.01	0.34
Female (REF: male)	59% (283)	−4.6	0.006	0.5	0.10
Hispanic/Latino (REF: not)	11% (53)	2.1	0.43	0.6	0.21
Race			0.94		0.83
White	72% (348)	REF		REF
Black	20% (96)	−1.1		0.2
Asian	3% (16)	0.7		0.1
Native American	<1% (1)	5.6		0.9
Other	4% (21)	2.2		0.9
Marital status			0.66		0.05
Single/never married	47% (225)	REF		REF
Married/living as married	31% (150)	−2.1		0.9
Divorced/separated	21% (100)	−1.3		0.8
Widowed	1% (7)	2.3		0.2
Clinical symptom severity
BISS total	56.1 + 18.8	−0.46	<0.001	0.09	<0.001
BISS depression	17.5 + 7.3	−1.64	<0.001	0.29	<0.001
BISS mania	9.2 + 6.4	0.23	0.08	−0.03	0.29
BISS anxiety	15.9 + 8.5	−0.92	<0.001	0.17	<0.001
BISS irritability	16.8 + 8.5	−0.65	<0.001	0.15	<0.001
BISS psychosis	2.8 + 4.5	−0.48	0.007	0.15	<0.001
Social disadvantage
Household income <$25 K (REF: ≥25 K)	52% (249)	−1.7	0.30	0.6	0.06
High school diploma or less (REF: at least some college)	25% (122)	−2.0	0.29	0.8	0.03
Unemployed/disabled (REF: employed/student/retired)	51% (244)	−3.1	0.06	0.7	0.03
Social disadvantage			0.07		0.03
No disadvantage	28% (133)	REF		REF
Mild	30% (142)	−1.1		0.6
Moderate	29% (138)	−5.3		0.8
Severe	13% (65)	−2.2		1.4
Current psychiatric comorbidity
Generalized anxiety disorder	22% (107)	−5.9	0.002	0.6	0.11
Substance use disorder	23% (109)	−0.6	0.76	0.2	0.49
Obsessive–compulsive disorder	11% (51)	−4.9	0.02	0.9	0.08
Panic disorder	23% (112)	−8.7	<0.001	0.8	0.03
Agoraphobia	37% (176)	−5.8	0.001	0.9	0.003
Social disorder	25% (119)	−5.3	0.005	0.8	0.03
ADHD	34% (161)	−4.2	0.02	1.0	0.002
Any anxiety disorder^a	58% (277)	−8.9	<0.001	1.2	<0.001

Q-LES-Q quality of life enjoyment and satisfaction questionnaire, LIFE-RIFT longitudinal interval follow-up evaluation-range of impaired functioning tool, REF reference level, BISS bipolar inventory of symptoms scale, ADHD attention deficit hyperactivity disorder. Coefficients and p values based on linear regression models. Coefficients represent the change in Q-LES-Q/LIFE-RIFT per 1-point increase for continuous variables and change from reference level for categorical variables
^aIncludes patients with any of the following current diagnoses (based on MINI): panic disorder, agoraphobia, social phobia, and generalized anxiety disorder

Back to article page