Table 3 Metabolic parameters in lithium-treated bipolar disorder patients

Baseline

312

797 ± 283

0.594 ± 0.201

25.9 ± 4.81

88.1 ± 14.3

23.7 ± 11.4

0.87 ± 0.19

94.2 ± 23.3

1

312

859 ± 282

0.638 ± 0.171

27.9 ± 5.87^a

90.5 ± 16.3

22.1 ± 10.4

0.86 ± 0.17

94.8 ± 22.2

2–5

1561

877 ± 296^a

0.658 ± 0.185

27.3 ± 5.10^a

90.9 ± 17.9

23.8 ± 10.8

0.87 ± 0.17

91.2 ± 21.1

6–10

1490

875 ± 310^a

0.656 ± 0.177

27.5 ± 5.15^a

97.4 ± 28.6^a

24.5 ± 11.2

0.90 ± 0.19

86.1 ± 20.1^a

11–15

1080

858 ± 320

0.672 ± 0.188

27.0 ± 4.57

95.3 ± 24.0^a

25.4 ± 11.7

0.91 ± 0.21

83.9 ± 20.2^a

16–20

739

815 ± 305

0.671 ± 0.191

27.6 ± 4.71^a

98.6 ± 28.4^a

26.9 ± 14.1

0.93 ± 0.24^a

78.8 ± 19.3^a

21–30

760

716 ± 289^a

0.651 ± 0.172

27.6 ± 4.30^a

103.8 ± 33.5^a

31.2 ± 15.7^a

0.98 ± 0.29^a

72.7 ± 20.1^a

≥31

201

647 ± 334^a

0.607 ± 0.168

26.6 ± 5.03

121.9 ± 54.9^a

33.1 ± 15.8^a

1.17 ± 0.48^a

62.2 ± 22.9^a

Means [95% CI]

312 subjects

833 ± 311 [824–842]

0.656 ± 0.184 [0.650–0.662]

27.0 ± 4.86 [26.5–27.5]

97.3 ± 28.4 [94.1–100.5]

26.1 ± 12.9 [24.7–27.5]

0.92 ± 0.24 [0.89–0.95]

83.3 ± 21.8 [80.9–85.7]

Change (%/year)

2669 assays

–0.777 [–0.654 to –0.901]

–0.005 [–0.118 to –0.118]

+0.162 [0.011–0.311]

+0.787 [0.619–0.954]

+1.41 [1.10–1.72]

+0.724 [0.609–0.839]

–0.915 [–0.822 to –1.01]

p value [t-score]

2669 assays

<0.0001 [12.4]

0.94 [0.077]

0.04 [2.11]

<0.0001 [9.21]

<0.0001 [8.91]

<0.0001 [12.4]

<0.0001 [19.1]