Fig. 1

Venn diagram displaying the overlap of comorbid AIA symptoms in BD-I mania. Sixteen patients (1.7%) were missing a value for one or more AIA symptom at baseline and are not shown on the figure. Anxiety was defined as a PANSS anxiety item score of ≥3 at baseline. Irritability was defined as a YMRS irritability item score of ≥4 at baseline. Agitation was defined as a YMRS increased motor activity–energy item score of ≥3 at baseline. Percentages are calculated from the full analysis set, which comprised 960 patients. AIA, anxiety, irritability, and agitation; BD-I, bipolar I disorder; PANSS, Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale