Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study

International Journal of Bipolar Disorders

Table 5 Log-rank test and Cox regression analysis of the time taken to enter CKD3b

	Univariate (Log-rank test)	Multivariate (Cox regression analysis)
	P value	Hazard ratio	95% CI	P value
Age^a	0.21	0.98	0.96–1.0	0.19
Sex	0.21	0.66	0.35–1.25	0.20
Treatment with antihypertensive drugs	0.74	1.02	0.64–1.60	0.93
Circulating thyroid antibodies	0.05	1.57	1.00–2.49	0.05
Treatment with l-thyroxine	0.91	0.83	0.52–1.34	0.45
Diabetes	0.49	0.93	0.56–1.57	0.80

^aIn the univariate analysis, three categories of age (< 45 years; 45–65 years; > 65 years) were used