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Table 2 Shewhart’s control rules sensitivity and PPV for predicting manic episodes within the next 4 weeks

From: Control charts for monitoring mood stability as a predictor of severe episodes in patients with bipolar disorder

 

Manic episodes

Episodes preceded by any rule activation

Rules activated

Rules followed by an episode

n

n

Sensitivity% (95% CI)

n

n

PPV% (95% CI)

Universal X-bar charts

 Short run-in period cohort

  Original dataa

53a

16a

30 (19, 45)a

439a

29a

7 (5, 9)a

  LVCF imputed data

53

18

34 (22, 48)

755

47

6 (5, 8)

 Long run-in period cohort

  Original data

25

14

56 (35, 75)

548

22

4 (3, 6)

  LVCF imputed data

25

15

60 (39, 78)

958

35

4 (3, 5)

Personalized X-bar charts

 Short run-in period cohort

  Original data

53

15

28 (17, 43)

666

29

4 (3, 6)

  LVCF imputed data

53

18

34 (22, 48)

1052

42

4 (3, 5)

 Long run-in period cohort

  Original data

25

10

40 (22, 61)

421

15

4 (2, 6)

  LVCF imputed data

25

12

48 (28, 68)

711

25

4 (2, 5)

Individual-moving range charts

 Short run-in period cohort

  Original data

   Individual chart

53

17

32 (20, 46)

944

35

4 (3, 5)

   Moving range chart

53

22

42 (28, 56)

1333

49

4 (3, 5)

  LVCF imputed data

   Individual chart

53

20

38 (25, 52)

1415

49

3 (3, 5)

   Moving range chart

53

27

51 (37, 65)

2027

76

4 (3, 5)

 Long run-in period cohort

  Original data

   Individual chart

25

10

40 (22, 61)

635

23

4 (2, 5)

   Moving range chart

25

13

52 (32, 72)

1078

27

3 (2, 4)

  LVCF imputed data

   Individual chart

25

11

44 (25, 65)

1012

34

3 (2, 5)

   Moving range chart

25

15

60 (39, 78)

1697

44

3 (2, 3)

  1. PPV positive predictive value, CI confidence interval, LVCF last value carried forward
  2. aResults from main analysis