Fig. 1

Example ApEn, adherence and drug holiday values for 100 days of data. In a–f, patients have few missing days but irregular daily dosage (high ApEn). In g, the patient has both a large number of missing days and irregular daily dosage. a Lamotrigine. ApEn 0.3432 with 94% adherence and 0 drug holidays. b Valproate. ApEn 0.4836 with 87% adherence and 2 drug holidays. c Lithium. ApEn 0.3511 with 97% adherence and 0 drug holidays. d Risperidone. ApEn 0.6007 with 80% adherence and 4 drug holidays. e Asenapine. ApEn 0.7117 with 86% adherence and 1 drug holiday. f Lamotrigine. ApEn 0.3756 with 99% adherence and 0 drug holidays. g Lamotrigine. ApEn 0.9428 with 65% adherence and 4 drug holidays