Table 1 Risk factors for treatment emergent affective switch
From: Antidepressants in bipolar depression: an enduring controversy
Bipolar I vs. bipolar II |
Mixed depressive features |
Rapid cycling |
Antidepressant subtype-TCAs > venlafaxine (?other SNRIs) > SSRIs or bupropion |
Substance abuse history, especially stimulants |