Fig. 2

Euthymic Bipolar patients vs healthy controls. a The main effect of group (across all conditions) is shown in red at a FWE corrected threshold p = 0.05. Bipolar patients showed higher activity than controls in the vmPFC, PCC, and parietal cortex. The group*attention interaction (BD > HC*internal > external focus) is shown in yellow, revealing clusters associated with internal focus that are also hyperactive in patients. b Switching from an internal to an external condition (int.ext) as compared to repeating an external condition (ext.ext) revealed higher activity in the entorhinal cortex for patients as compared to controls (in red, BD > HC*int.ext > ext.ext). The group*valence interaction (BD > HC*int(neg).ext > int(pos).ext) for switching from internal to external focus is shown in yellow, indicating a modulation of switching due to the valence of the previous trial