TY - JOUR AU - Jauhar, Sameer AU - Young, Allan H. PY - 2019 DA - 2019/03/27 TI - Controversies in bipolar disorder; role of second-generation antipsychotic for maintenance therapy JO - International Journal of Bipolar Disorders SP - 10 VL - 7 IS - 1 AB - In this narrative review, we discuss use of second-generation antipsychotics (SGAs) in maintenance treatment of bipolar disorder. We compare their use to historically more established treatments (particularly lithium, the gold standard). To compare we review evidence on efficacy, effectiveness and tolerability across illness poles, possible mechanisms of treatment response, guidance given by guideline groups and pragmatic clinical considerations. We then illustrate the controversies in maintenance antipsychotic use, with the example of first episode mania and its treatment within first episode psychosis services. Finally, we make suggestions for future studies to unpick these differences. SN - 2194-7511 UR - https://doi.org/10.1186/s40345-019-0145-0 DO - 10.1186/s40345-019-0145-0 ID - Jauhar2019 ER -