Fig. 6From: Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary reportMacrophage activity impairment occurs in parallel with the progression of BD. Cell death, DAMPs release, telomere shortening, and proinflammatory mediators might lead to a chronic state of immune dysfunction, with a consequent decline in critical cellular processes. The immune system failures to counterbalance inflammatory responses, accelerates cell aging and leads to structural and neurocognitive changes with consequent loss of maintenance of tissue homeostasis and healthBack to article page