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International Journal of Bipolar Disorders
Fig. 4 | International Journal of Bipolar Disorders

Fig. 4

From: Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents

Fig. 4

Log BDNF-2 methylation percentage by study group from the longitudinal model between Time 1 and Time 2. Estimated longitudinal profiles of log BDNF-2 methylation rates. After adjustment, there was evidence that the rate of decrease in controls (green) is steeper than the rate of decrease of affected HR (red) (p = 0.0140, t-value = − 2.55), and marginally steeper than in unaffected HR (blue) (p = 0.0624, t-value = − 1.91). There was no evidence that the change over time of affected HR (red) was different from unaffected HR (blue) (p = 0.4384, t-value = 0.78)

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