Investigating the association between anxiety symptoms and mood disorder in high-risk offspring of bipolar parents: a comparison of Joint and Cox models

International Journal of Bipolar Disorders

Table 3 Cox model with frailty (n = 156). 95% CI = 95% confidence interval

Variable	Estimate (95% CI)	p-value
\(log{\text{HAMA }}\)	0.642 (0.165, 1.118)	0.008
Female offspring	0.539 (− 0.279, 1.357)	0.200^a
Male offspring	*
Lithium responder parent Lithium non-responder parent	0.463 (− 0.471, 1.397) *	0.330
SES 123	− 0.177 (− 1.479, 1.125)	0.135^a
SES 4	0.410 (− 0.573, 1.392)
SES 5	*
Parent onset age	− 0.006 (− 0.052, 0.041)	0.810
Age at initial interview	0.019 (− 0.087, 0.125)	0.720
Family frailty	-	0.250

* = Reference level
^ap-value obtained by a partial likelihood ratio test on 2 degrees of freedom; other p-values obtained by Wald tests