TY - JOUR AU - Lee, Sheng-Yu AU - Wang, Tzu-Yun AU - Chen, Shiou-Lan AU - Chang, Yun-Hsuan AU - Chen, Po-See AU - Huang, San-Yuan AU - Tzeng, Nian-Sheng AU - Wang, Liang-Jen AU - Lee, I-Hui AU - Chen, Kao-Ching AU - Yang, Yen-Kuang AU - Hong, Jau-Shyong AU - Lu, Ru-Band PY - 2020 DA - 2020/03/02 TI - Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial JO - International Journal of Bipolar Disorders SP - 11 VL - 8 IS - 1 AB - The aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma brain-derived neurotrophic factor (BDNF), cytokine levels, and metabolic profiles in patients with bipolar spectrum disorder. SN - 2194-7511 UR - https://doi.org/10.1186/s40345-019-0174-8 DO - 10.1186/s40345-019-0174-8 ID - Lee2020 ER -