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Table 3 Summary of previous and current medications for the maintenance therapy in the combination group

From: Defining phenotypes of long-term lithium and valproate response, including combination therapy: a modified application of the Alda scale in patients with bipolar disorders

Case

Previous medication

Combination of LiVal

Lith1

Val2

Lamo3

AAP4

Lith + AAP5

Val + AAP6

Current medication

Ordera

1

X

X

X

X

X

O

LiVal + AAP

Val → LiVal

2

X

X

X

O

X

O

LiVal + AAP

Val → LiVal

3

X

X

X

X

X

O

LiVal + AAP

Val → LiVal

4

X

X

X

O

X

O

LiVal + AAP

Val → LiVal

5

X

X

X

O

O

X

LiVal + AAP

Lith → LiVal

6

X

X

O

X

O

O

LiVal + AAP

Val → Lith → LiVal

7

X

X

X

O

O

X

LiVal + AAP

Lith → LiVal

8

X

X

X

X

O

O

LiVal + AAP

Lith → Val → LiVal

9

X

O

X

X

X

X

LiVal

Val → LiVal

10

X

X

X

X

O

O

LiVal + AAP

Lith → Val → LiVal

11

X

X

X

O

O

O

LiVal + AAP

Lith → Val → LiVal

12

O

O

X

O

O

O

LiVal + AAP

Val → Lival → Lith → LiVal

13

X

O

O

X

O

O

LiVal + AAP

Val → LiVal → Val → LiVal

14

X

O

X

O

X

O

LiVal + AAP

Val → LiVal

15

X

X

X

O

O

O

LiVal + AAP

Lith → LiVal

16

X

O

O

X

X

X

LiVal + Lamo

Val → LiVal

17

X

X

X

X

O

O

LiVal + AAP

Lith → Val → LiVal

  1. Lith, lithium; Val, valproate; AAP, any atypical antipsychotic medication; LiVal, lithium and valproate combination; Lamo, lamotrigine
  2. aThe order in which lithium and valproate were administered
  3. 1Lithium monotherapy
  4. 2VALPROATE monotherapy
  5. 3Lamotrigine with or without lithium, valproate, and antipsychotics
  6. 4Atypical antipsychotics monotherapy
  7. 5Lithium with atypical antipsychotics
  8. 6Valproate with atypical antipsychotics