Table 1 Characteristics of patients with bipolar disorder (BD), unaffected relatives (UR) and healthy controls (HC)
BD | UR | HC | p† | |
|---|---|---|---|---|
n | 31 | 22 | 35 | |
Age (median [IQR]) | 29 [25–32.5] | 24 [22–28.5] | 28 [25–31.5] | 0.008 |
Male sex, n (%) | 11 (35.5) | 6 (27.3) | 12 (34.3) | 0.803 |
Dark eyes, n (%) | 7 (22.6) | 2 (9.1) | 6 (17.1) | 0.454 |
Time of assessment, minutes (mean (SD)) | 263 (143) | 292 (154) | 302 (150) | 0.578 |
Daylength, minutes (median [IQR]) | 778 [685–943] | 915 [813–955] | 852 [703–972] | 0.176 |
HDRS (median [IQR]) | 8 [5.5–13] | 1 [0–2] | 0 [0–1.5] | < 0.001 |
YMRS (median [IQR]) | 2 [0–7] | 0 [0–1] | 0 [0–0] | < 0.001 |
Bipolar type 2, n (%) | 22 (71) | |||
Current phase, n (%) | ||||
Remission | 9 (29.0) | |||
Depression | 7 (22.6) | |||
Hypomania/mixed | 3 (9.7) | |||
Lithium, n (%) | 12 (38.7) | |||
Lamotrigine, n (%) | 18 (58.1) | |||
Antipsychotic, n (%) | 15 (48.4) | |||
Antidepressant, n (%) | 6 (19.4) | |||
Number of agents, n (%) | ||||
0 | 0 (0) | |||
1 | 10 (32.3) | |||
2 or more | 21 (67.7) | |||