| |
BD (n = 31)
|
UR (n = 22)
|
p
|
HC (n = 35)
|
p
|
p
|
|---|
|
Mean
|
95% CI
|
Mean
|
95% CI
|
BD-UR
|
Mean
|
95% CI
|
BD-HC
|
UR-HC
|
|---|
|
Blue light
|
|
PIPRlate
|
0.31
|
0.27–0.35
|
0.34
|
0.29–0.39
|
0.29
|
0.35
|
0.31–0.39
|
0.20
|
0.87
|
|
PDbaseline (mm)
|
7.09
|
6.81–7.40
|
7.53
|
7.17–7.89
|
0.13
|
7.32
|
7.04–7.60
|
0.28
|
0.35
|
|
Cmax
|
0.62
|
0.60–0.64
|
0.63
|
0.61–0.65
|
0.50
|
0.62
|
0.60–0.64
|
0.80
|
0.29
|
|
Red light
|
|
PDbaseline (mm)
|
7.10
|
6.81–7.38
|
7.57
|
7.23–7.90
|
0.10
|
7.31
|
7.03–7.58
|
0.28
|
0.22
|
|
Cmax
|
0.49
|
0.46–0.52
|
0.48
|
0.45–0.51
|
0.56
|
0.51
|
0.48–0.54
|
0.33
|
0.14
|
| |
Comparisons of UR and HC with BD in current remission
| |
|---|
|
Remission (n = 9)
| | | | | | |
|---|
|
Blue light
|
|
PIPRlate
|
0.26
|
0.20–0.33
|
0.33
|
0.28–0.38
|
0.34
|
0.35
|
0.31–0.38
|
0.04
|
0.67
|
|
PDbaseline (mm)
|
7.04
|
6.49–7.61
|
7.53
|
7.17–7.89
|
0.38
|
7.32
|
7.04–7.60
|
0.38
|
0.36
|
|
Cmax
|
0.60
|
0.56–0.64
|
0.63
|
0.61–0.65
|
0.15
|
0.62
|
0.60–0.64
|
0.36
|
0.35
|
|
Red light
|
|
PDbaseline (mm)
|
7.08
|
6.55–7.60
|
7.57
|
7.23–7.91
|
0.36
|
7.31
|
7.03–7.58
|
0.44
|
0.23
|
|
Cmax
|
0.44
|
0.39–0.49
|
0.48
|
0.44–0.51
|
0.42
|
0.51
|
0.48–0.54
|
0.02
|
0.13
|
- PIPRlate The mean post-illumination pupillary contraction measured at 10–30 s after stimulation, PDbaseline mean pupil diameter during the 10 s before illumination; Cmax mean pupillary contraction at 3–5 s during illumination. Remission is defined as Hamilton Depression Rating Scale and Young Mania Rating Scale < 8
