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International Journal of Bipolar Disorders
Fig. 1 | International Journal of Bipolar Disorders

Fig. 1

From: Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus

Fig. 1

Experimental design. Glutamatergic neurons in the mPFC of rats were transduced with D1R or dsRed. After recovery from virus injection rats were treated for 7 continuous days with DOX to induce virus over-expression. In one half of the subjects, virus over-expression was maintained and is referred to as ‘ON’. The ‘OFF’ group was not further provided with DOX after initial 7 days of virus over-expression. Behavioral experiments (EPM: Elevated Plus Maze and MB: Marble burying) were performed on day 11 and 12, respectively. Subjects were sacrificed via perfusion on day 15 and immunohistochemistry (IHC) was performed afterwards

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