Fig. 2

Anxiety behavior and compulsive activity accessed in the Elevated Plus Maze and Marble Burying paradigm indicated through time in open arm, open arm entries, latency till first open arm entry and amount of buried marbles. Virus over-expression (‘ON’) is terminated (‘OFF’) following doxycycline removal. a Anxiety as measured time spent in the open arm [%]. b Anxiety behavior was also determined as number of open arm entries. c Risky behavior as measured as latency till first open arm entry. d D1R ‘OFF’ animals buried significantly more marbles than their control group (dsRed ‘OFF’) and D1R ‘ON’ subjects. Means ± SEM are presented for n = 6 subject for each group. *Represent p < 0.05 Bonferroni correction indicating significant differences between relevant groups