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Table 1 Comparison of BCN participants in the US and Europe

From: 25 Years of the International Bipolar Collaborative Network (BCN)

Clinical characteristics United States (N = 676) Europe (N = 292)
Early onset (< 19 y) 69.2%*** 32.3%
Delay to first treatment for depression (age of onset < 19 y) 13.1 y* 8.4 y
Delay to first treatment for mania (age of onset < 19 y) 11.3y*** 5.8y
Prospective nonresponders 51.7%*** 31.1%
Life time history of   
 Anxiety disorder 46.6%*** 28.1%
 Alcohol abuse 33.1%*** 14.7%
 Substance Abuse 38.3%*** 17.8%
 Rapid Cycling 74.1%*** 41.5%
 > 20 Episodes 59.0%*** 23.3%
 Hospitalizations Fewer** More
  1. Burden of illness appears significantly higher in the US subjects (*p < 0.05; **p < 0.01; ***p =  < 0.001)