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Table 2 Sociodemographic and clinical characteristics

From: Impact of modification to DSM-5 criterion A for hypomania/mania in newly diagnosed bipolar patients: findings from the prospective BIO study

Patients, n

373

Total visits

849

Sex

 

 Male, n (%)

128 (34%)

 Female, n (%)

245 (66%)

Bipolar subtype

 

 BD I, n (%)

120 (32%)

 BD II, n (%)

253 (68%)

Years of education, median (IQR)

15 (13–17)

No. of previous hospitalizations/admissions, median (IQR)

0 (0–1)

Family history of BDa, n (%)

56 (16%)

Age (years), median (IQR)

32 (27–40)

Age at onset (years)b, median (IQR)

18 (15–22)

Age at first hypomanic/manic episode (years)c, median (IQR)

21 (17–27)

Illness duration (years)d, median (IQR)

10 (6–16)

Delay in diagnosis (years)e, median (IQR)

5 (2–11)

Follow up time in study (months), median (IQR)

41 (26–50)

Follow up time in study (years), median (IQR)

3 (2–4)

No. of visits contributed per patient, median (IQR)

2 (1–3)

YMRS total score, median (IQR)

3 (0–6)

Modified YMRS total scoref, median (IQR)

1 (0–4)

No. of patients fulfilling a depressed visit through follow up (Hamilton ≥ 15), n (%)

135 (36%)

No. of patients fulfilling a visit with DSM-IV criterion A for hypomania/mania through follow up, n (%)

127 (34%)

No. of patients fulfilling a visit with DSM-5 criterion A for hypomania/mania through follow up, n (%)

63 (17%)

Baseline visits (first visit by each subject), n

373

YMRS total score at first visit, median (IQR)

3 (0–6)

Modified YMRS total score at first visit, median (IQR)

1 (0–4)

No. of patients fulfilling DSM-IV criterion A for hypomania/mania at baseline, n (%)

86 (23%)

No. of patients fulfilling DSM-5 criterion A for hypomania/mania at baseline, n (%)

33 (9%)

YMRS total score for participants fulfilling DSM-IV criterion A at first visits, median (IQR)

10 (7–14)

Modified YMRS total score for participants fulfilling DSM-IV criterion A at first visits, median (IQR)

5 (2–8)

YMRS total score for participants fulfilling DSM-5 criterion A at first visits, median (IQR)

14 (10–16)

Modified YMRS total score for participants fulfilling DSM-5 criterion A at first visits, median (IQR)

8 (4–10)

No. of patients with a depressive episode at first visit (Hamilton ≥ 15) at baseline, n (%)

101 (27%)

  1. aFamily history of BD: Mother, father or sibling with bipolar disorder
  2. bAge at onset: From birthdate to first episode of depression, mania, hypomania or mixed episode
  3. cAge at first hypomanic/manic episode: From birthdate to first mania, hypomania or mixed episode
  4. dIllness duration: From first episode (depression, mania, hypomania or mixed episode) to date of inclusion
  5. eDelay in diagnosis: From the time where the first mania, hypomania or mixed episode occurred to date of the diagnosis of a single manic or mixed episode or a diagnosis of BD
  6. fModified YMRS total score = total score minus item 1, item 2 and item 5