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Table 3 Logistic regression—prediction of DSM-5 criterion A fulfillment in 373 subjects

From: Impact of modification to DSM-5 criterion A for hypomania/mania in newly diagnosed bipolar patients: findings from the prospective BIO study

Variable OR 95% CL p-value
Age (years)
 Univariate analysis 0.99 0.97, 1.02 0.65
Sex (Male vs female)
 Univariate analysis 0.95 0.53, 1.68 0.86
 Multivariate analysisf 0.79 0.37, 1.67 0.53
No. of visits contributed
 Univariate analysis 1.51 1.31, 1.75 < 0.0001
 Multivariate analysisf 1.86 1.52, 2.29 < 0.0001**
Bipolar subtype (BD I vs BD II)
 Univariate analysis 1.50 0.85, 2.61 0.16
 Multivariate analysisf 1.64 0.82, 3.27 0.16
Age at onset (years)a
 Univariate analysis 0.97 0.92, 1.01 0.11
Age first hypomanic/manic episode (years)b
 Univariate analysis 0.96 0.92, 0.99 0.03
 Multivariate analysisf 0.99 0.94, 1.04 0.57
Delay in diagnosis (years)c
 Univariate analysis 1.02 0.99, 1.06 0.15
 Multivariate analysisf 1.03 0.98, 1.07 0.25
No. of visits with depressed symptoms
 Univariate analysis 1.34 0.99, 1.81 0.06
 Multivariate analysisf 0.78 0.51, 1.19 0.24
Mean modified YMRS total scored
 Univariate analysis 1.38 1.24, 1.52 < 0.0001
 Multivariate analysisf 1.51 1.34, 1.71 < 0.0001**
Number of previous hospitalizations/ admissions
 Univariate analysis 0.92 0.74, 1.14 0.44
Education years
 Univariate analysis 0.92 0.83, 1,02 0.12
 Multivariate analysisf 0.90 0.78, 1.03 0.13
Family history of BDe (no vs yes)
 Univariate analysis 0.79 0.35, 1.77 0.57
 Multivariate analysisf 0.71 0.26, 1.97 0.52
  1. aAge at onset: From birthdate to first episode of depression, mania, hypomania or mixed episode
  2. bAge at first hypomanic/manic episode: From birthdate to first mania, hypomania or mixed episode
  3. cDelay in diagnosis: From first mania, hypomania or mixed episode to date of BD diagnosed
  4. dMean of the modified YMRS total score (YMRS total score minus item 1, item 2 and item 5) across patient visits
  5. eFamily history of BD: Mother, father or sibling with bipolar disorder
  6. fAdjusted for bipolar subtype, sex, no. of visits contributed, age first hypomanic/manic episode (years), no. of visits with depressed symptoms, mean modified YMRS total score, family history of BD, delay in diagnosis, education years
  7. **Remained statistically significant after Bonferroni correction for multiple testing in the multivariate analysis (p < 0.006)