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Table 5 Odds ratios of experiencing irritability depending on the different manic symptoms (YMRS items) during 849 visits

From: Impact of modification to DSM-5 criterion A for hypomania/mania in newly diagnosed bipolar patients: findings from the prospective BIO study

   OR 95% confidence limits Range of scalea
Item 1 (Mood) Unadjusted 1.6 (1.4, 2.0) 0–4
  Adjustedb 1.1 (0.8, 1.4)  
Item 2 (Energy/activity) Unadjusted 1.6 (1.4, 2.0) 0–4
  Adjusted 1.1 (0.8, 1.4)  
Item 3 (Sexual interest) Unadjusted 1.6 (1.3, 2.1) 0–3
  Adjusted 1.2 (0.9, 1.6)  
Item 4 (Sleep) Unadjusted 1.6 (1.3, 2.0) 0–4
  Adjusted 1.3 (1.0, 1.6)  
Item 5 (Irritability) X x x 0–6
Item 6 (Speech) Unadjusted 1.4 (1.2, 1.5) 0–6
  Adjusted 1.1 (0.9, 1.2)  
Item 7 (Language-Thought Disorder) Unadjusted 1.8 (1.6, 2.2) 0–4
  Adjusted 1.5* (1.3, 1.9)*  
Item 8 (Content) Unadjusted 1.5 (1.3, 1.8) 0–8
  Adjusted 1.0 (0.8, 1.3)  
Item 9 (Aggression) Unadjusted 2.5 (1.4, 4.5) 0–5
  Adjusted 2.2 (1.1, 4.2)  
Item 10 (Appearance) Unadjusted 2.4 (1.3, 4.6) 0–4
  Adjusted 1.2 (0.6, 2.6)  
Item 11 (Insight) Unadjusted 1.2 (0.8, 1.9) 0–6
  Adjusted 0.7 (0.4, 1.3)  
  1. Outcome irritability > 0 vs irritability = 0
  2. aRange of scale: observed minimum and maximum values of the individual YMRS items in data set
  3. bAdjusted model is adjusted for all the remaining YMRS items: Item 1, Item 2, item 3, item 4, item 6, item 7, item 8, item 9, item 10, item 11
  4. *Remained statistically significant after adjustment and Bonferroni correction for multiple testing (p < 0.005)