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Table 4 Studies that investigated reappraisal in risk groups

From: Deficits in explicit emotion regulation in bipolar disorder: a systematic review

Study Age Medication Paradigm Dependent variables Results behavioral Results neural
Heissler et al. (2014) Young adults No Task:
Picture viewing task
Valence:
Negative, positive
Participants:
High HPS scores (n = 22)
HC (n = 24)
Behavioral:
Self-report during and after the task
Neural:
fMRI
Regions of interest:
Emotions reactivity: Amygdala, subgenual ACC, VMPFC, occipital and ventral temporal cortices, thalamus; Emotion regulation: OFC, DLPFC, DMPFC, dACC, parietal cortex, precuneus
Rating after the experiment:
Arousal: Risk group > HC
Viewing condition:
NS
Reappraisal:
NS
Viewing:
Negative vs. neutral: Right Amygdala: Risk group > HC
Positive vs. neutral: NS
Reappraisal vs. viewing:
Negative:
Right Amygdala: Risk group > HC
Positive: NS
Kanske et al. (2015) Adults No Task:
Picture viewing task
Valence:
Negative, positive
Participants:
FDR (n = 17)
HC (n = 17)
Behavioral:
Self-report during and after the task
Neural:
fMRI, PPI
Regions of interest:
Bilateral OFC, dorsolateral (DLPFC, middle frontal) and dorsomedial prefrontal (DMPFC, superior medial), anterior cingulate (ACC), and parietal cortex (inferior, superior)
PPI seed:
Amygdala
PPI targets:
OFC, dorsolateral (DLPFC, middle frontal) and dorsomedial prefrontal (DMPFC, superior medial), anterior cingulate (ACC) and parietal cortex (inferior, superior)
Rating after the experiment:
Risk group > HC (all pictures more positive)
Viewing:
Positive: Risk group < HC
Negative: NS
Reappraisal:
Risk group < HC
Viewing:
NS
Reappraisal vs. viewing:
Amygdala: Risk group > HC
PPI:
Left amygdala/bilateral OFC: HC, negative connectivity; Risk group, positive connectivity
Right amygdala/right OFC: HC, negative connectivity; Risk group, positive connectivity
Ajaya et al. (2016) Young adults No Task:
Videogame task
Valence:
Negative
Participants:
Undergraduates (n = 66)
Behavioral:
self-reported affect, facial expressions
Psychophysiology:
Respiratory sinus arrhythmia (RSA)
Higher HPS scores increased RSA during ER (only in the deliberated reappraisal condition) X
  1. ACC anterior cingulate cortex, dACC dorsal anterior cingulate DLPFC, dorsolateral prefrontal cortex, DMPFC dorsomedial prefrontal cortex, fMRI functional magnetic resonance imaging, HC healthy controls, HPS hypomanic personality scale, OFC orbitofrontal cortex, PFC prefrontal cortex, PPI psychophysiological interaction, VLPFC ventrolateral prefrontal cortex, VMPFC ventromedial prefrontal cortex