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Table 2 The eight extra epidemiological studies reported on by Van Meter et al. (2019a)

From: ‘Pediatric Bipolar Disorder’ rates are still lower than claimed: a re-examination of eight epidemiological surveys used by an updated meta-analysis

Source

Subjects

Location

Year completed

Criteria

Instrument

Prevalence period

Age

Informant

Critique

Van Meter et al. (2019a)

Parry et al. (2020) – this paper

BD-I %

Undifferentiated

BD-I %/BD-II %

Total Bipolar Spectrum %

BD-I %

Total Bipolar Spectrum %

Päären et al. 2014

N = 2,300

Sweden

1991-1993

DSM-III-R

BDI-C

CES-DC

Attempted Suicide

DICA-R-A

Lifetime

16–17 years

Youth report only.

Methodology does not allow for accurate community prevalence.

Two stage screening with depression questionnaires followed by a diagnostic interview for hypomania.

0.04

-

4.0

1/2,300 = 0.04% fulfilled criteria for a manic episode.

Hypomania spectrum: 90/2,300 = 3.9%; (full 1.7%, brief 0.8%, sub-syndromal 1.4%).

Total bipolar spectrum = 3.94%

Adult follow-up 15 years later:

Sole adolescent BD-I case not reported.

2/64 (3%) adolescent hypomania spectrum developed mania/adult BD-I.

3/130(2%) adolescent MDD developed mania/adult BD-I.

Adult follow-up 15 years later:

4/64 (6%) adolescent hypomania spectrum had hypomania/BD-II in adulthood. Total bipolar spectrum = 9% of this cohort.

13/130 (10%) adolescent MDD had hypomania/BD-II in adulthood. Total bipolar spectrum = 12% of this cohort.

Tijssen et al. 2010

N = 1,395 or 705

Germany

1994

Follow-up 1996, 2002

DSM-IV

DIA-X/M-CIDI

Lifetime

14–17 years

Youth report only.

37 cases in 1,395 identified as at least 4 days hypomanic/manic lifetime symptoms, but these excluded from follow-up cohort of 705, as study focused on development of new symptoms.

-

2.7

14.3

Not defined

37/1,395 = 2.65%

8-year follow-up of cohort of 705 adolescents excluding 37 original total bipolar spectrum subjects: No further episodes hypomania/mania emerged, many manic and depressive symptoms, authors don't define cases.

Roberts et al. 2007

N = 4,175

Texas, USA

2000

DSM-IV

DISC-IV

12 mth

11–17 years

Youth report only for diagnosis.

Divided results according to whether impairment criteria of DISC-IV or CGAS were applied or not.

0.4

1.2

-

0.39 (with/out impairment)

0.31 (DISC impairment)

0.22 (CGAS impairment)

1.2 (with/out impairment)

0.31 (DISC impairment)

0.31 (CGAS impairment)

Kozloff et al. 2010

N = 5,673

Canada

2002

DSM-IV

CIDI

Lifetime

15–24 years

Youth report only.

Diagnoses on DSM-IV criteria but more liberal duration criteria of “several days or longer”.

2.0

-

-

Not defined

All ages 15–24 years

15–18 years

19–24 years

3.0

2.1

3.8

Anselmi et al. 2009

N = 4,452

Brazil

2005-2006 

DSM-IV/   ICD-10

DAWBA

[Estimated prevalence reads as cases in diagnostic phase. Formula in stats section]

11–12 years

Child plus mother informants combined with psychiatrist adjudication where discrepant.

0

-

-

0

0

Pan et al. 2014

N = original sample = 9,937;

final sample = 1554 high-risk + 958 random-selection = 2512

Brazil

2009 screening 

2010-2011

DSM-IV

DAWBA

Lifetime

6–12 years

Parents of 9937 6–12-year-old children interviewed Family History Survey.

A sample of 2512 random + high-risk children selected for parent interview DAWBA.

Parent/caregiver only informant.

‘Exuberant’ hypomanic symptoms not associated with impairment or psychopathology.

‘Under-control’ hypomanic symptoms overlap with ADHD and ODD/ CD.

-

0.2

1.8

0.2 (BD-I/ BD-II)

0.2a

1.8

1.4a

Vizard et al. 2018

N = 9,117

England

2017

ICD-10

DAWBA

Lifetime

2–19 years

2–4-year-old (parent)

5–10-year-old (parent + teacher)

11–16-year-old (parent + youth + teacher)

17–19-year-old (parent + youth)

0.1

-

-

Not definedb

0.0 (5–16-year-olds)

0.1 (17–19-year-olds)

NB by age/gender the two groups with cases were 11–16-year-old boys (0.1%)c and 17–19-year-old girls (0.3%)

Karacetin et al. 2018

N = 5,842

Turkey

K-SADS-PL

Lifetime

2014–2015 Turkish school year

7–10 years

Parent only

0

0

0

0

0

  1. a“Weighted prevalence” – personal communication Pan-Parry (2019)
  2. bICD-10 F-30/F-31 codes include “mania/hypomania/BD-I/BD-II/BD-undifferentiated”
  3. cPersonal communication Ford-Parry (2019) indicated “youngest case bipolar spectrum disorder was 16-years-old”