Outcomeb | Baseline | 3-month follow-up | 6-month follow-up | 9-month follow-up | 15-month follow-up | SMC (Med, range) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ThrIVe-B | TAU | ThrIVe-B | TAU | ThrIVe-B | TAU | ThrIVe-B | TAU | ThrIVe-B–TAUc (95% CI) | ThrIVe-B | TAU |  | |
PHQ-9a | 15.5 (6.6) n = 21 | 12.9 (5.2) n = 20 | 10.4 (5.4) n = 12 | 11.4 (6.1) n = 16 | 10.6 (5.6) n = 14 | 12.3 (7.7) n = 17 | 10.3 (6.5) n = 12 | 9.8 (4.9) n = 17 | − 0.2 (− 4.6; 4.2) | 10.7 (7.2) n = 11 | 8.9 (5.5) n = 17 | 2 (0–20) n = 20 |
BRQa | 2036 (342) n = 19 | 1923 (369) n = 16 | 1969 (503) n = 13 | 1988 (416) n = 17 | 1951 (493) n = 11 | 1927 (427) n = 14 | 2124 (327) n = 13 | 1886 (404) n = 16 | 349 (107; 591) | 2238 (483) n = 9 | 1929 (350) n = 16 | 447 (2–1903) n = 19 |
QoL-BDa | 33.2 (7.5) n = 20 | 36.6 (6.8) n = 20 | 34.2 (9.7) n = 13 | 34.0 (7.9) n = 17 | 34.1 (8.3) n = 14 | 34.1 (9.6) n = 17 | 35.1 (8.3) n = 14 | 34.0 (10.7) n = 17 | 2.4 (− 5.2; 9.9) | 35.0 (10.7) n = 10 | 34.5 (9.8) n = 16 | 4 (0–38) n = 20 |
ALS totala | 37.3 (6.1) n = 22 | 31.5 (13.1) n = 21 | 23.8 (13.3) n = 13 | 27.2 (11.7) n = 15 | 24.9 (8.1) n = 14 | 27.0 (12.0) n = 17 | 26.0 (13.5) n = 14 | 23.5 (12.2) n = 17 | − 1.6 (− 8.4; 5.3) | 26.6 (15.2) n = 10 | 21.6 (11.1) n = 16 | 5 (0–37) n = 21 |
ALS depression-elation subscale | 17.5 (3.3) n = 22 | 14.9 (6.7) n = 21 | 10.2 (6.0) n = 13 | 12.9 (5.7) n = 15 | 10.8 (5.4) n = 14 | 13.3 (5.8) n = 17 | 12.8 (6.8) n = 13 | 12.2 (5.5) n = 17 | − 1.5 (− 4.6; 1.6) | 13.1 (7.1) n = 10 | 11.1 (5.7) n = 16 | – |
GAD-7 | 11.2 (4.7) n = 19 | 10.4 (5.1) n = 20 | 11.3(4.9) n = 13 | 9.2 (5) n = 17 | 11.5 (5.1) n = 14 | 8.1 (4.6) n = 17 | 9.3 (5.4) n = 14 | 7.5 (5.9) n = 17 | 1.4 (− 2.9; 5.6) | 7.8 (4.5) n = 10 | 8.7 (7.3) n = 16 | 2 (0–11) n = 20 |
HDRS | 12.8 (8.1) n = 22 | 6.6 (4.2) n = 19 | NR | NR | NR | NR | 8.5 (4.8) n = 13 | 9.5 (5.8) n = 16 | − 2.6 (− 7.6; 2.3) | 8.2 (7.8) n = 11 | 6.1 (3.0) n = 17 | – |
Mean SRM | 5.1 (2.9) n = 17 | 4.6 (2.1) n = 17 | 5.6 (0.8) n = 11 | 5.5 (2.8) n = 14 | 3.9 (2.0) n = 10 | 3.6 (2.1) n = 12 | 5.5 (1.9) n = 11 | 4.9 (1.0) n = 10 | 0.5 (− 1.5; 2.5) | 5.0 (1.2) n = 8 | 5.5 (0.8) n = 13 | – |
BMRS | 1.8 (2.4) n = 21 | 1.7 (1.8) n = 21 | NR | NR | NR | NR | 1.8 (3.2) n = 13 | 1.9 (2.5) n = 17 | 0.4 (− 1.6; 2.4) | 1.8 (3.6) n = 11 | 1.0 (1.8) n = 17 | – |
BARS | 2.8 (0.7) n = 18 | 2.9 (0.5) n = 19 | NR | NR | NR | NR | 3.8 (0.8) n = 10 | 3.9 (0.4) n = 15 | 0.0 (− 0.5; 0.5) | 3.9 (0.2) n = 8 | 3.8 (0.8) n = 14 | – |
MEPS | 3.1 (2.4) n = 21 | 3.4 (2.2) n = 19 | NR | NR | NR | NR | 3.7 (2.6) n = 11 | 2.6 (1.2) n = 16 | 1.6 (− 0.1; 3.3) | 4.1 (2.6) n = 11 | 2.6 (1.4) n = 17 | – |
UPPS-P | 160.9 (23.8) n = 20 | 164.3 (25.0) n = 19 | 158.6 (23.3) n = 13 | 152.8 (23.0) n = 17 | 156.8 (22.5) n = 13 | 158.1 (21.9) n = 17 | 149.5 (25.7) n = 14 | 153.5 (21.8) n = 17 | − 6.7 (− 16.0; 2.6) | 147.5 (28.7) n = 10 | 154.3 (24.8) n = 16 | – |
BADS | 71.4 (23.4) n = 20 | 78.5 (26.5) n = 19 | 81.9 (24.5) n = 13 | 73.5 (25.1) n = 16 | 74.5 (33.1) n = 12 | 72.9 (27.4) n = 16 | 80.2 (21.5) n = 14 | 75.1 (33.1) n = 17 | 7.4 (− 13.3; 28.2) | 85.6 (30.3) n = 10 | 76.6 (30.6) n = 16 | – |
KIMS total | 114.5 (19.1) n = 20 | 114.8 (21.3) n = 20 | 117.2 (22.7) n = 12 | 117.1 (24.7) n = 17 | 116.2 (24.2) n = 13 | 116.3 (21.9) n = 16 | 125.4 (22.9) n = 14 | 117.9 (25.9) n = 16 | 13.1 (4.9; 21.3) | 128.1 (21.3) n = 10 | 115.4 (25.7) n = 16 | – |