Using density of antecedent events and trajectory path analysis to investigate family-correlated patterns of onset of bipolar I disorder: a comparison of cohorts from Europe and USA

International Journal of Bipolar Disorders

Table 1 Characteristics of 573 individuals with BD-I (209 with a family history and 364 without a family history of BD)

	Cumulative probability		Median age at onset in years (interquartile range)
	Number	(%)^c	Median age at onset in years (interquartile range)
Females	322	56.2
Family history of BD	209	36.5
Age at onset of BD			22.0 (18.0, 30.5)
Duration of BD			16.0 (11.5, 25.3)
Lifetime comorbidities:
≥ 1 comorbid mental disorder^a	301	52.5
Age at onset of first mental disorder^b			18.0 (14.3, 25.5)
Social phobia	81	14.2	15.0 (11.5, 20.3)
Specific phobia	49	8.5	15.5 (10.3, 22.5)
Obsessive compulsive disorder	28	5.0	18.3 (14.0, 23.0)
Generalized anxiety disorder	45	7.9	20.8 (17.0, 27.5)
Agoraphobia	53	9.4	20.0 (15.3, 36.0)
Panic disorder	108	18.9	22.0 (17.5, 32.3)
Eating disorder	56	9.8	16.8 (14.0, 18.3)
Cannabis abuse	88	15.4	17.8 (17.0, 20.5)
Cannabis dependence	38	6.7	18.3 (16.5, 21.8)
Alcohol abuse	124	21.7	23.5 (18.3, 35.0)
Alcohol dependence	45	7.8	28.5 (21.3, 35.0)

^aComorbid mental disorder refers to any DSM IV diagnosed disorder that occurred (irrespective of BD-I mood episodes);
^bFirst mental disorder refers to a clinical condition that met criteria for a full-threshold DSM IV diagnosis
^cDenominator for comorbid disorders ranges from n = 549 to n = 573 (due to small number of sporadic missing values)