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Table 2 Fisher’s exact test of response and remission rates and treatment-emergent manic/hypomanic episodes

From: Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial

  ITTa PPb
Sham Active p Sham Active p
Responsec
 Week 3 3 (11) 3 (12) 1 3 (12) 3 (13) 1
 Sustained at week 6 2 (7) 2 (8) 1 2 (9) 2 (9) 1
 Sustained at week 12 2 (7) 2 (8) 1 2 (11) 2 (9) 1
Remissiond
 Week 3 0 (0) 1 (4) 0.48 0 (0) 1 (4) 0.48
 Sustained at week 6 0 (0) 1 (4) 0.48 0 (0) 1 (4) 1
 Sustained at week 12 0 (0) 1 (4) 0.48 0 (0) 1 (5) 1
Manic or hypomanic episodes by week 4 3 (11) 8 (31) 0.095 3 (12) 7 (30) 0.16
  1. aSham n = 28, treatment n = 26
  2. bSham n at week 3, 6 and 12 = 25, 23, 19; treatment n at week 3, 6 and 12 = 23, 23, 22
  3. cResponse defined as 50% reduction in MADRS from baseline and CGI ≤ 2
  4. dRemission defined as MADRS < 7 and CGI = 1