Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial

International Journal of Bipolar Disorders

Table 2 Fisher’s exact test of response and remission rates and treatment-emergent manic/hypomanic episodes

	ITT^a			PP^b
	Sham	Active	p	Sham	Active	p
Response^c
Week 3	3 (11)	3 (12)	1	3 (12)	3 (13)	1
Sustained at week 6	2 (7)	2 (8)	1	2 (9)	2 (9)	1
Sustained at week 12	2 (7)	2 (8)	1	2 (11)	2 (9)	1
Remission^d
Week 3	0 (0)	1 (4)	0.48	0 (0)	1 (4)	0.48
Sustained at week 6	0 (0)	1 (4)	0.48	0 (0)	1 (4)	1
Sustained at week 12	0 (0)	1 (4)	0.48	0 (0)	1 (5)	1
Manic or hypomanic episodes by week 4	3 (11)	8 (31)	0.095	3 (12)	7 (30)	0.16

^aSham n = 28, treatment n = 26
^bSham n at week 3, 6 and 12 = 25, 23, 19; treatment n at week 3, 6 and 12 = 23, 23, 22
^cResponse defined as 50% reduction in MADRS from baseline and CGI ≤ 2
^dRemission defined as MADRS < 7 and CGI = 1