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Table 2 Linear regression predicting yearly eGFR change

From: Estimated glomerular filtration rate in Korean patients exposed to long-term lithium maintenance therapy

  Crude coefficient (95% CI) Crude p Adjusted coefficient (95% CI) Adjusted p
Age − 0.26 (− 1.94, 1.42) 0.764 − 2.39 (− 4.84, 0.05) 0.056
Sex (men vs. women) − 13.37 (− 66.81, 40.07) 0.624 − 20.04 (− 75.92, 35.84) 0.482
Baseline hypertension − 11.69 (− 107.43, 84.05) 0.811 − 7.87 (− 112.71, 96.96) 0.883
Baseline diabetes − 0.47 (− 145.63, 144.69) 0.995 25.83 (− 128.75, 180.41) 0.743
Primary psychiatric diagnoses, ICD-10 (ref.  = F20–29)
 F30–31 − 16.45 (− 85.42, 52.53) 0.640 − 14.45 (− 86.41, 57.52) 0.694
 F32–33 53.15 (− 27.04, 133.35) 0.194 62.95 (− 20.88, 146.78) 0.142
Drug (lithium vs. valproate) − 7.5 (− 64.9, 49.9) 0.798 − 3.57 (− 81.89, 74.76) 0.929
Baseline eGFR − 1.03 (− 2.49, 0.43) 0.168 − 2.17 (− 4.15, − 0.20) 0.031
Average daily dose − 0.03 (− 0.17, 0.1) 0.629 0.02 (− 0.15, 0.18) 0.857
Years on treatment 0.01 (− 5.34, 5.36) 0.997 − 1.47 (− 7.07, 4.14) 0.608
Episodes of lithium toxicity (≥ 1 episode)
 TDM  > 0.8 mmol/L − 5.27 (− 78.89, 68.36) 0.888 2.78 (− 114.5, 120.06) 0.963
 TDM  > 1.0 mmol/L − 7.50 (− 182.52, 167.53) 0.933 − 9.05 (− 220.15, 202.06) 0.933
 TDM  > 1.2 mmol/L − 7.77 (− 108.68, 93.14) 0.880 1.54 (− 150.36, 153.43) 0.984