Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores

International Journal of Bipolar Disorders

Table 2 Multivariate logistic regression analysis with lifetime suicide attempt as the dependent variable

	Odds ratio	95% CI	P
PRS for suicide attempt as the independent variable
PRS for suicide attempt	1.32	1.05–1.66	0.018
Age	0.97	0.95–1.00	0.026
Sex, female	1.27	0.78–2.07	0.334
Diagnosis, bipolar II disorder	1.96	1.22–3.16	0.006
Study center, SNUBH	1.26	0.77–2.07	0.356
1st principal component^a	0.29	0.00–24.07	0.587
2nd principal component^a	0.80	0.01–66.14	0.920
PRS for obsessive–compulsive disorder as the independent variable
PRS for obsessive–compulsive disorder	1.32	1.05–1.66	0.017
Age	0.98	0.95–1.00	0.028
Sex, female	1.29	0.79–2.09	0.312
Diagnosis, bipolar II disorder	1.99	1.24–3.21	0.005
Study center, SNUBH	1.31	0.80–2.15	0.285
1st principal component^a	0.18	0.00–15.05	0.448
2nd principal component^a	0.95	0.01–78.63	0.982

PRS polygenic risk score, SNUBH Seoul National University Bundang Hospital
^aFive outlier samples were removed after visual inspection of the multidimensional scaling plots, then the principal components were recalculated