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Table 3 Multivariate logistic regression analysis using five polygenic risk scores

From: Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores

  Odds ratio 95% CI P
Multivariate model using five PRSs
 PRS for suicide attempt 1.36 1.08–1.72 0.009
 PRS for bipolar disorder 1.18 0.94–1.47 0.146
 PRS for schizophrenia 0.80 0.64–1.00 0.052
 PRS for major depressive disorder 1.21 0.97–1.52 0.096
 PRS for obsessive–compulsive disorder 1.33 1.06–1.66 0.015
Multivariate model using five PRSs with additional adjustments
 PRS for suicide attempt 1.32 1.04–1.67 0.021
 PRS for bipolar disorder 1.21 0.96–1.52 0.106
 PRS for schizophrenia 0.82 0.64–1.04 0.097
 PRS for major depressive disorder 1.14 0.90–1.44 0.267
 PRS for obsessive–compulsive disorder 1.29 1.02–1.63 0.031
 Age 0.98 0.95–1.00 0.035
 Sex, female 1.29 0.79–2.12 0.315
 Diagnosis, bipolar II disorder 1.83 1.12–2.99 0.015
 Study center, SNUBH 1.26 0.76–2.08 0.374
 1st principal componenta 0.35 0.00–32.84 0.651
 2nd principal componenta 0.86 0.01–79.46 0.947
  1. PRS polygenic risk score, SNUBH Seoul National University Bundang Hospital
  2. aFive outlier samples were removed after visual inspection of the multidimensional scaling plots, then the principal components were recalculated