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Table 3 Multivariate logistic regression analysis using five polygenic risk scores

From: Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores

 

Odds ratio

95% CI

P

Multivariate model using five PRSs

 PRS for suicide attempt

1.36

1.08–1.72

0.009

 PRS for bipolar disorder

1.18

0.94–1.47

0.146

 PRS for schizophrenia

0.80

0.64–1.00

0.052

 PRS for major depressive disorder

1.21

0.97–1.52

0.096

 PRS for obsessive–compulsive disorder

1.33

1.06–1.66

0.015

Multivariate model using five PRSs with additional adjustments

 PRS for suicide attempt

1.32

1.04–1.67

0.021

 PRS for bipolar disorder

1.21

0.96–1.52

0.106

 PRS for schizophrenia

0.82

0.64–1.04

0.097

 PRS for major depressive disorder

1.14

0.90–1.44

0.267

 PRS for obsessive–compulsive disorder

1.29

1.02–1.63

0.031

 Age

0.98

0.95–1.00

0.035

 Sex, female

1.29

0.79–2.12

0.315

 Diagnosis, bipolar II disorder

1.83

1.12–2.99

0.015

 Study center, SNUBH

1.26

0.76–2.08

0.374

 1st principal componenta

0.35

0.00–32.84

0.651

 2nd principal componenta

0.86

0.01–79.46

0.947

  1. PRS polygenic risk score, SNUBH Seoul National University Bundang Hospital
  2. aFive outlier samples were removed after visual inspection of the multidimensional scaling plots, then the principal components were recalculated