Inclusion criteria | Exclusion criteria |
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• English-speaking adults at least 18 years old • History of DSM-IV bipolar I disorder, confirmed by Structured Clinical Interview • Experiencing hypomania or mania with a score on Young Mania Rating Scale ≥ 15 and meeting DSM-IV criteria for a current hypomanic, manic, or mixed episode • Desire to seek treatment for bipolar I disorder • Written informed consent obtained and willingness to perform study procedures confirmed • Agree to taper existing ineffective medications and be randomized to one of the three study conditions • No use of antidepressants for 1 month prior to randomization (3 months for fluoxetine) | • Patients who are euthymic (well) on their current medications • Patients who are already taking combination DVP + Li or DVP + QTP • Patients with a history of partial or nonresponse to DVP, Li, QTP, or any combination of those medications, documented by serum levels • History of intolerance or toxicity to DVP, Li, or QTP • History of adverse experiences to DVP, Li, or QTP • Disorders that would contraindicate or limit the use of Li, including dermatological conditions, such as psoriasis or acne vulgaris, or kidney failure • Disorders that would contraindicate the use of DVP, including clinically significant active hepatitis or hepatic failure as evidenced by abnormal laboratory values • Impaired cardiac function as evidenced by positive EKG in subjects age 50 or over • Patients with unstable medical illnesses within the past 2 months • Current suicidal ideation or intent • Substance abuse or dependency within the past month • Pregnant (i.e., positive urine pregnancy test) or nursing women or planning to conceive |