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Table 3 Reported side effects of at least moderate intensity judged to be possibly, probably, or definitely related to study medication

From: A pilot trial of quetiapine, lithium, or placebo added to divalproex sodium for hypomanic or manic episodes in ambulatory adults with bipolar I disorder

  Entire cohort
N = 75
DVP + PBO
n = 24
DVP + Li
n = 25
DVP + QTP
n = 26
Average number of side effects reported 5.4 (2.6) 6.5 (2.2) 4.5 (2.4) 5.4 (3.0)
Increased appetite 34 (45.3%) 11 (14.7%) 12 (16%) 11 (14.7%)
Sedation 32 (42.7%) 9 (12%) 2 (2.7%) 21 (28%)
Dry mouth 29 (38.7%) 6 (8%) 8 (10.7%) 15 (20%)
Nausea 25 (33.3%) 8 (10.7%) 9 (12%) 8 (10.7%)
Tiredness 23 (30.7%) 7 (9.3%) 4 (5.3%) 12 (16%)
Increased thirst 21 (28%) 2 (2.7%) 7 (9.3%) 12 (16%)
Upset stomach 21 (28%) 8 (10.7%) 7 (9.3%) 6 (8%)
Diarrhea 20 (26.7%) 9 (12%) 7 (9.3%) 4 (5.3%)
Gastrointestinal problems 18 (24%) 7 (9.3%) 8 (10.7%) 3 (4%)
Increased urinary frequency 16 (21.3%) 3 (4%) 9 (12%) 4 (5.3%)
Word finding difficulties 14 (18.7%) 1 (1.3%) 6 (8%) 7 (9.3%)
Slurred speech 10 (13.3%) 0 (0%) 3 (4%) 7 (9.3%)
Ataxia* 10 (13.3%) 0 (0%) 3 (4%) 7 (9.3%)
Weakness 9 (12%) 2 (2.7%) 2 (2.7%) 5 (6.7%)
Dizzy/lightheaded 9 (12%) 0 (0%) 2 (2.7%) 7 (9.3%)
Edema 9 (12%) 3 (4%) 2 (2.7%) 4 (5.3%)
Impaired memory 9 (12%) 1 (1.3%) 3 (4%) 5 (6.7%)
Feeling dull 9 (12%) 0 (0%) 2 (2.7%) 7 (9.3%)
Cognitive slowing 9 (12%) 0 (0%) 2 (2.7%) 7 (9.3%)
Joint/muscle aches 9 (12%) 4 (5.3%) 2 (2.7%) 3 (4%)
Tactile sensations 7 (9.3%) 1 (1.3%) 1 (1.3%) 5 (6.7%)
Increased appetite 34 (45.3%) 11 (14.7%) 12 (16%) 11 (14.7%)
  1. *Significant at p < 0.05