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Table 5 Longitudinal Outcomes in YMRS and HAM-D: monotherapy versus individual combination therapies

From: A pilot trial of quetiapine, lithium, or placebo added to divalproex sodium for hypomanic or manic episodes in ambulatory adults with bipolar I disorder

Predictors

YMRS

HAM-D

Estimates

CI

p

Estimates

CI

p

Group [Li]

1.80

− 1.77–5.37

0.319

2.29

− 0.87–5.45

0.153

Group [QTP]

− 0.83

− 4.36–2.69

0.640

0.66

− 2.46–3.78

0.675

Time [days]

− 0.13

− 0.18 to − 0.08

< 0.001***

− 0.05

− 0.09 to − 0.02

0.004**

Site [VA]

0.41

− 3.31–4.13

0.826

− 4.60

− 8.14 to − 1.07

0.011*

Group [Li] × time

− 0.06

− 0.14–0.01

0.108

− 0.00

− 0.06–0.05

0.878

Group [QTP] × time

0.00

− 0.06–0.07

0.919

0.04

− 0.01–0.09

0.124

  1. PBO: monotherapy divalproex plus placebo [reference group]; Li: combination therapy of divalproex plus blinded lithium; QTP: divalproex plus blinded quetiapine; VA: Palo Alto VA
  2. *p < 0.05, **p < 0.01, ***p < 0.001